Recent advances in drug discovery of GPCR allosteric modulators for neurodegenerative disorders

被引：15

作者：

Lutjens, Robert ^{[1
]}

Rocher, Jean-Philippe ^{[2
]}

机构：

[1] Addex Therapeut, Geneva, Switzerland

[2] Inst Rech Pierre Fabre, CNS Innovat Unit, Toulouse, France

来源：

CURRENT OPINION IN PHARMACOLOGY | 2017年 / 32卷

关键词：

METABOTROPIC GLUTAMATE RECEPTORS; PROTEIN-COUPLED RECEPTORS; AMYOTROPHIC-LATERAL-SCLEROSIS; LEVODOPA-INDUCED DYSKINESIAS; CENTRAL-NERVOUS-SYSTEM; PARKINSONS-DISEASE; MOUSE MODEL; ALZHEIMERS-DISEASE; CNS DISORDERS; L-DOPA;

D O I：

10.1016/j.coph.2017.01.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The activation or the inhibition of G-protein coupled receptors (GPCRs) implicated in the pathophysiology of neurodegenerative disorders is considered as a relevant approach for the treatment of these diseases. The modulation of the relevant GPCRs targets by positive or by negative allosteric modulators appears to be promising, the major challenge remaining the discovery of these molecules. In this review, we highlight the recent development in this field and the therapeutic potential of selected GPCRs allosteric modulators.

引用

页码：91 / 95

页数：5

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