Chemokines and chemokine receptors in inflammatory bowel disease: Recent findings and future perspectives

被引：18

作者：

Camba-Gomez, Miguel ^{[1
]}

Arosa, Laura ^{[1
]}

Gualillo, Oreste ^{[2
,3
]}

Conde-Aranda, Javier ^{[1
]}

机构：

[1] Hlth Res Inst Santiago Compostela IDIS, Mol & Cellular Gastroenterol, Santiago De Compostela, Spain

[2] Santiago Univ Clin Hosp, SERGAS Serv Galego Saude, Santiago De Compostela, Spain

[3] Santiago Univ Clin Hosp, IDIS Inst Invest Sanitaria Santiago, NEIRID Lab Neuroendocrine Interact Rheumatol & In, Res Lab 9, Santiago De Compostela, Spain

来源：

DRUG DISCOVERY TODAY | 2022年 / 27卷 / 04期

关键词：

Chemokines; Intestinal inflammation; Leukocyte trafficking; Resolution of inflammation; Epithelial barrier; INDUCTION THERAPY; EXPERIMENTAL COLITIS; LY6C(HI) MONOCYTES; PROMOTES COLITIS; DENDRITIC CELLS; INFLAMED COLON; T-CELLS; ANTAGONIST; CCR9; MACROPHAGES;

D O I：

10.1016/j.drudis.2021.12.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Despite the benefits of current therapeutic options for treating inflammatory bowel disease (IBD), there are still patients who are refractory to these therapies. Moreover, the relapses caused by incomplete intestinal mucosa healing are frequent. Therefore, there is a need for novel pharmacological targets that can improve the existing IBD therapeutic armamentarium. Chemokine and chemokine receptors have emerged as appealing options to this end. As well as controlling leukocyte trafficking to inflamed tissues, these proteins regulate many other processes related to the development of intestinal inflammation. In this review, we summarise the most recent preclinical studies, along with the putative application of chemokine-based therapies in patients with IBD.

引用

页码：1167 / 1175

页数：9

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