Plasma levels of interleukin-18 and interleukin-18 binding protein are elevated in patients with chronic liver disease

被引:95
|
作者
Ludwiczek, O
Kaser, A
Novick, D
Dinarello, CA
Rubinstein, M
Vogel, W
Tilg, H
机构
[1] Univ Innsbruck Hosp, Dept Med, Div Gastroenterol & Hepatol, A-6020 Innsbruck, Austria
[2] Weizmann Inst Sci, Dept Mol Genet, IL-76100 Rehovot, Israel
[3] Univ Colorado, Hlth Sci Ctr, Denver, CO USA
基金
奥地利科学基金会;
关键词
cytokines; chronic liver disease; cirrhosis;
D O I
10.1023/A:1020600230977
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Interleukin 18 (IL-18) is a recently described proinflammatory cytokine. In mouse models it has been shown to play a key role in the development of liver injury. IL-18 binding protein (IL-18BP) is a naturally occurring antagonist of IL-18. In this study we investigated whether IL-18/IL-18BP levels are altered in patients with chronic liver disease (CLD). We measured IL-18 and IL-18BP plasma levels in 153 patients with CLD and 41 healthy controls by a specific ELISA. Plasma levels of IL-18 were significantly higher in CLD patients than in healthy controls. Cirrhotics had higher levels than noncirrhotics. IL-18 levels increased with disease progression. IL-18BP plasma levels paralled the increase of IL-18 with disease progression, except in stage Child C cirrhosis. IL-18 and IL-18BP levels were elevated independent of the etiology of CLD. IL-18 and IL-18BP correlated with laboratory parameters of inflammation and liver injury. Plasma levels of IL-18 and its antagonist, IL-18BP, are elevated in CLD and correlate with severity of disease. IL-18BP may not be sufficient to counteract the overwhelming proinflammatory response in end stage liver disease.
引用
收藏
页码:331 / 337
页数:7
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