Metallothionein expression in benign and malignant canine mammary gland tumours

被引：4
|
作者：
Erginsoy, S. D.
Sozmen, M. [1 ]
Caldin, M.
Furlanello, T.
机构：
[1] Kafkas Univ, Fac Vet Med, Dept Pathol, TR-36100 Kars, Turkey
[2] Vet Clin, Padua, Italy
[3] Lab San Marco, Padua, Italy
来源：
RESEARCH IN VETERINARY SCIENCE | 2006年 / 81卷 / 01期
关键词：
dog; mammary tumour; metallothionein; immunohistochemistry;
D O I：
10.1016/j.rvsc.2005.09.013
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The presence of metallothioneins (MTs) were demonstrated immunohistochemically using a monoclonal antibody (E9) against a conserved epitope of 1 and 11 isoforms in canine mammary tumours. In a semiquantitative analysis MT expression in the tumour cells was observed in 54/54 cases of benign and 32/40 malignant mammary neoplasms. A statistically significant difference at the level of P < 0.01 was observed for MT expression between benign and malign mammary tumours in terms of immunoreactivity score. It is concluded that immunohistochemically demonstrated MT expression is significantly associated with benign canine mammary tumours. (c) 2005 Elsevier Ltd. All rights reserved.
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收藏
页码：46 / 50
页数：5
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