Micropaleontological analyses of a sediment core raised in Disko Bugt (West of Greenland) were undertaken in order to document paleoceanographical changes in the eastern Baffin Bay during the Holocene. The modern analogue technique (MAT) applied to dinocyst assemblages provided information on paleo-sea-surface conditions, whereas isotopic analyses of benthic foraminifers aimed at documenting the deep' water mass occupying the site. During the earlier interval recorded (similar to 10 to similar to 7.3cal.kyrBP), important discharge of ice and meltwater from the Greenland Ice Sheet (GIS) margin, notably through the Jakobshavn Isbrae, resulted in harsh conditions with a dense sea-ice cover and low temperatures, productivity, and foraminiferal abundances. Postglacial conditions settled at similar to 7.3cal.kyrBP, with a sharp rise in dinocyst abundance and species diversity, which led to reconstruct increase in summer temperatures. We link this transition to the advection of West Greenland Current waters in the upper part of the water column after the reduction of meltwater inputs from GIS. Optimal temperature conditions reaching up to >10 degrees C were finally achieved in surface waters at similar to 6cal.kyrBP. Slight cooling pulses were then recorded at similar to 4.2-4 and similar to 1.5-1cal.kyrBP, and the final optimum recorded in surface temperature from similar to 1 to 0.8cal.kyrBP is associated with the Medieval Warm Period'. Throughout the postglacial interval, the data suggest an opposition between sea-surface temperatures and salinity, with warmer intervals being characterized by lower salinity waters, probably as a result of the higher freshwater discharge along the ice margin and notably the Jakobshavn Isbrae.