Does Serum Urate Change as Parkinson's Disease Progresses?

被引：3
|
作者：
Hasimoglu, Yasemin G. [1 ]
Chen, Xiqun [1 ]
Bakshi, Rachit [1 ]
Schwarzschild, Michael A. [1 ]
Macklin, Eric A. [2 ]
机构：
[1] Massachusetts Gen Hosp, Dept Neurol, MassGen Inst Neurodegenerat Dis, Boston, MA 02114 USA
[2] Massachusetts Gen Hosp, Dept Med, Biostat Ctr, Boston, MA 02114 USA
来源：
JOURNAL OF PARKINSONS DISEASE | 2020年 / 10卷 / 04期
基金：
美国国家卫生研究院;
关键词：
Parkinson's disease; urate; disease progression; longitudinal study; BODY-MASS INDEX; URIC-ACID; ASSOCIATION;
D O I：
10.3233/JPD-202064
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Higher serum urate concentration is associated with decreased risk of Parkinson's disease (PD) as well as slower disease progression, but its relationship with severity of PD remains unclear. This study investigated whether changes in serum urate concentration over 5 years were associated with disease progression assessed by MDS-UPDRS Part III score, Hoehn and Yahr stage, or DaTscan imaging. Average serum urate concentration was stable over time and change in serum urate concentration did not correlate with worsening of measures of PD progression. These results suggest that serum urate concentration is not a monitoring biomarker of PD progression in early stages.
引用
收藏
页码：1571 / 1576
页数：6
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