Myelodysplastic syndrome with t(9;22)(p24;q11.2), a BCR-JAK2 fusion: case report and review of the literature

被引：10
|
作者：
Kantarcioglu, Bulent [1 ,4 ]
Kaygusuz-Atagunduz, Isik [2 ]
Uzay, Ant [3 ]
Toptas, Tayfur [2 ]
Tuglular, Tulin Firatli [2 ]
Bayik, Mahmut [2 ]
机构：
[1] Istanbul Medipol Univ, Dept Internal Med, Div Hematol, Istanbul, Turkey
[2] Marmara Univ, Dept Internal Med, Div Hematol, Istanbul, Turkey
[3] Acibadem Univ, Dept Internal Med, Div Hematol, Istanbul, Turkey
[4] Medipol Mega Hosp Complex, Hematol Clin, TR-34214 Istanbul, Turkey
来源：
INTERNATIONAL JOURNAL OF HEMATOLOGY | 2015年 / 102卷 / 03期
关键词：
t(9; 22); Myelodysplastic syndrome; BCR-JAK2; Fusion gene; JAK2; rearrangement; CHRONIC EOSINOPHILIC LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; CHRONIC MYELOID-LEUKEMIA; JAK2; TRANSLOCATION; PATIENT; GENE; RUXOLITINIB; REARRANGEMENTS; DISORDERS;
D O I：
10.1007/s12185-015-1792-2
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The human JAK2 gene is mainly targeted by two types of genetic lesions that play roles in the pathogenesis of hematologic malignancies: intragenic mutations and chromosomal translocations. Chromosomal translocations of JAK2 are typically associated with myeloid or lymphoid malignancies with an aggressive course and poor outcome. Here we report a t(9;22)(p24;q11.2) translocation, in a MDS patient and review results associated with BCR-JAK2 fusion reported in the literature.
引用
收藏
页码：383 / 387
页数：5
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