A Unified Strategy Towards N-Aryl Heterocycles by a One-Pot Copper-Catalyzed Oxidative C-H Amination of Azoles

被引：24
|
作者：
Subramanian, Parthasarathi [1 ]
Kaliappan, Krishna P. [1 ]
机构：
[1] Indian Inst Technol, Dept Chem, Bombay 400076, Maharashtra, India
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 2014卷 / 27期
关键词：
Synthetic methods; C-H activation; Amination; Nitrogen heterocycles; Copper; Reaction mechanisms; BOND FORMATION SYNTHESIS; REDUCTIVE ELIMINATION; COUPLING REACTION; FUNCTIONALIZATION; ROUTE; DERIVATIVES; ACTIVATION; AMIDATION; ARYLATION; ANILINES;
D O I：
10.1002/ejoc.201402868
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient one-pot synthesis of N-aryl-substituted heterocycles by a Cu-catalyzed two-fold C-N bond formation is reported. This strategy involves a Cu-I-catalyzed C-N bond-forming reaction between azoles and electron-deficient bromopyridines followed by an intramolecular sp(2) C-H amination. One of the products thus formed has been successfully used as a ligand for the synthesis of a Pd complex.
引用
收藏
页码：5986 / 5997
页数：12
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