Clinical trials in pulmonary sarcoidosis

被引：5
|
作者：
Baughman, Robert P. [1 ]
Lower, Elyse E. [1 ]
Saketkoo, Lesley Ann [2 ]
机构：
[1] Univ Cincinnati, Med Ctr, Dept Med, Cincinnati, OH 45267 USA
[2] Tulane Univ, Lung Ctr, New Orleans Scleroderma & Sarcoidosis Patient Car, New Orleans, LA 70118 USA
来源：
CURRENT OPINION IN PULMONARY MEDICINE | 2015年 / 21卷 / 05期
基金：
美国国家卫生研究院;
关键词：
forced vital capacity; high resolution CT scan; patient recorded outcome measures; quality of life; six-minute walk test; 6-MINUTE WALK TEST; BRITISH-THORACIC-SOCIETY; FATIGUE ASSESSMENT SCALE; QUALITY-OF-LIFE; DOUBLE-BLIND; HEALTH-STATUS; CORTICOSTEROID-THERAPY; INFLAMMATORY ACTIVITY; INFLIXIMAB THERAPY; F-18-FDG PET;
D O I：
10.1097/MCP.0000000000000193
中图分类号：
R56 [呼吸系及胸部疾病];
学科分类号：
摘要：
Purpose of reviewSeveral new agents have been investigated in sarcoidosis. As the outcome measures in these trials has varied, it is often difficult to compare different treatment regimens or to combine clinical trials of the same regimen. The present review will assess the various potential endpoints, including physiologic, chest imaging, and health-related quality of life.Recent findingsIndividual endpoints in pulmonary sarcoidosis trials have been studied and compared to response to several drugs. A panel of sarcoidosis experts as convened to enumerate the various potential endpoints and also voted on the relative importance of these endpoints as primary and secondary endpoints in sarcoidosis clinical trials.SummaryThere are several potential endpoints in clinical trials. These endpoints may also prove useful in clinical practice.
引用
收藏
页码：525 / 531
页数：7
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