Diagnosis and Treatment of Growth Hormone Deficiency: A Position Statement from Korean Endocrine Society and Korean Society of Pediatric Endocrinology

被引：16

作者：

Kim, Jung Hee ^{[1
]}

Chae, Hyun Wook ^{[2
]}

Chin, Sang Ouk ^{[3
]}

Ku, Cheol Ryong ^{[4
]}

Park, Kyeong Hye ^{[5
]}

Lim, Dong Jun ^{[6
]}

Kim, Kwang Joon ^{[7
]}

Lim, Jung Soo ^{[8
]}

Kim, Gyuri ^{[9
]}

Choi, Yun Mi ^{[10
]}

Ahn, Seong Hee ^{[11
]}

Jeon, Min Ji ^{[12
]}

Hwangbo, Yul ^{[13
]}

Lee, Ju Hee ^{[14
]}

Kim, Bu Kyung ^{[15
]}

Choi, Yong Jun ^{[16
]}

Lee, Kyung Ae ^{[17
]}

Moon, Seong-Su ^{[18
]}

Ahn, Hwa Young ^{[19
]}

Choi, Hoon Sung ^{[20
]}

Hong, Sang Mo ^{[10
]}

Shin, Dong Yeob ^{[4
]}

Seo, Ji A. ^{[21
]}

Kim, Se Hwa ^{[22
]}

Oh, Seungjoon ^{[3
]}

Yu, Sung Hoon ^{[23
]}

Kim, Byung Joon ^{[24
]}

Shin, Choong Ho ^{[25
]}

Kim, Sung-Woon ^{[3
]}

Kim, Chong Hwa ^{[26
]}

Lee, Eun Jig ^{[4
]}

机构：

[1] Seoul Natl Univ, Seoul Natl Univ Hosp, Dept Internal Med, Coll Med, Seoul, South Korea

[2] Yonsei Univ, Dept Pediat, Coll Med, Seoul, South Korea

[3] Kyung Hee Univ, Dept Endocrinol & Metab, Sch Med, Seoul, South Korea

[4] Yonsei Univ, Dept Internal Med, Div Endocrinol & Metab, Coll Med, 50-1 Yonsei Ro, Seoul 03722, South Korea

[5] Natl Hlth Insurance Serv Ilsan Hosp, Dept Internal Med, Div Endocrinol & Metab, Goyang, South Korea

[6] Catholic Univ Korea, Coll Med, Dept Internal Med, Div Endocrinol & Metab, Seoul, South Korea

[7] Yonsei Univ, Dept Internal Med, Div Geriatr, Coll Med, Seoul, South Korea

[8] Yonsei Univ, Dept Internal Med, Wonju Coll Med, Wonju, South Korea

[9] Sungkyunkwan Univ, Thyroid Ctr, Samsung Med Ctr, Div Endocrinol & Metab,Dept Med,Sch Med, Seoul, South Korea

[10] Hallym Univ, Hallym Univ Dongtan Sacred Heart Hosp, Dept Internal Med, Coll Med, Hwaseong, South Korea

[11] Inha Univ, Dept Endocrinol, Sch Med, Incheon, South Korea

[12] Univ Ulsan, Asan Med Ctr, Dept Internal Med, Coll Med, Seoul, South Korea

[13] Natl Canc Ctr, Dept Internal Med, Goyang, South Korea

[14] Chungnam Natl Univ, Dept Internal Med, Coll Med, Daejeon, South Korea

[15] Kosin Univ, Dept Internal Med, Coll Med, Busan, South Korea

[16] Ajou Univ, Dept Endocrinol & Metab, Sch Med, Suwon, South Korea

[17] Res Inst Clin Med Jeonbuk Natl Univ, Dept Internal Med, Div Endocrinol & Metab, Biomed Res Inst Jeonbuk Natl Univ Hosp, Jeonju, South Korea

[18] Dongguk Univ, Dept Internal Med, Coll Med, Gyeongju, South Korea

[19] Chung Ang Univ, Dept Internal Med, Coll Med, Seoul, South Korea

[20] Kangwon Natl Univ, Dept Internal Med, Sch Med, Chunchon, South Korea

[21] Korea Univ, Korea Univ Ansan Hosp, Dept Internal Med, Div Endocrinol,Coll Med, Ansan, South Korea

[22] Catholic Kwandong Univ, Dept Internal Med, Int St Marys Hosp, Coll Med, Incheon, South Korea

[23] Hanyang Univ, Hanyang Univ Guri Hosp, Dept Endocrinol & Metab, Coll Med, Guri, South Korea

[24] Gachon Univ, Dept Internal Med, Div Endocrinol, Coll Med, Incheon, South Korea

[25] Seoul Natl Univ, Dept Pediat, Coll Med, Seoul, South Korea

[26] Sejong Gen Hosp, Dept Internal Med, Div Endocrinol & Metab, 28 Hohyeon Ro 489 Beon-gil, Bucheon 14754, South Korea

来源：

ENDOCRINOLOGY AND METABOLISM | 2020年 / 35卷 / 02期

关键词：

Growth hormone; Dwarfism; pituitary; Hypopituitarism; Hormone replacement therapy; GH REPLACEMENT THERAPY; GLUCAGON STIMULATION TEST; BONE-MINERAL DENSITY; CARDIOVASCULAR RISK-FACTORS; BODY-MASS INDEX; QUALITY-OF-LIFE; HYPOPITUITARY PATIENTS; ADULT PATIENTS; PLUS ARGININE; FACTOR-I;

D O I：

10.3803/EnM.2020.35.2.272

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Growth hormone (GH) deficiency is caused by congenital or acquired causes and occurs in childhood or adulthood. GH replacement therapy brings benefits to body composition, exercise capacity, skeletal health, cardiovascular outcomes, and quality of life. Before initiating GH replacement, GH deficiency should be confirmed through proper stimulation tests, and in cases with proven genetic causes or structural lesions, repeated GH stimulation testing is not necessary. The dosing regimen of GH replacement therapy should be individualized, with the goal of minimizing side effects and maximizing clinical improvements. The Korean Endocrine Society and the Korean Society of Pediatric Endocrinology have developed a position statement on the diagnosis and treatment of GH deficiency. This position statement is based on a systematic review of evidence and expert opinions.

引用

页码：272 / 287

页数：16

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