Effects of ursolic acid on different steps of the angiogenic process

被引：100
|
作者：
Cárdenas, C
Quesada, AR
Medina, MA [1 ]
机构：
[1] Univ Malaga, Fac Sci, Dept Mol Biol & Biochem, E-29071 Malaga, Spain
[2] Univ Malaga, Cent Culture Cell Serv, E-29071 Malaga, Spain
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 320卷 / 02期
关键词：
ursolic acid; triterpenoid; angiogenesis; endothelial cells; BAEC;
D O I：
10.1016/j.bbrc.2004.05.183
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Ursolic acid is a triterpenoid with pleiotropic biological effects. In this report, we study the effects of ursolic acid on different key steps of angiogenesis. Our results show that ursolic acid is able to inhibit key steps of angiogenesis in vitro, including endothelial cell proliferation, migration, and differentiation. At the same time, it seems to stimulate other key steps of angiogenesis, such as extracellular matrix degradation by MMP-2 and urokinase. Although ursolic acid can inhibit in vivo angiogenesis in the CAM assay, the different signs of the effects it causes on different steps of angiogenesis force one to be cautious concerning its anti-angiogenic potential. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码：402 / 408
页数：7
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