Dependence of Pharmacokinetics and Biodistribution on Polymer Architecture: Effect of Cyclic versus Linear Polymers

被引：201

作者：

Nasongkla, Norased ^{[1
,2
,4
]}

Chen, Bo ^{[1
,2
]}

Macaraeg, Nichole ^{[1
,2
]}

Fox, Megan E. ^{[3
]}

Frechet, Jean M. J. ^{[3
]}

Szoka, Francis C. ^{[1
,2
]}

机构：

[1] Univ Calif San Francisco, Sch Pharm, Dept Biopharmaceut Sci, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Sch Pharm, Dept Pharmaceut Chem, San Francisco, CA 94143 USA

[3] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

[4] Mahidol Univ, Fac Engn, Dept Biomed Engn, Nakhon Pathom, Thailand

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2009年 / 131卷 / 11期

关键词：

MOLECULAR-WEIGHT; DENDRIMERS; DELIVERY; CHAINS; ROUTE; DRUG;

D O I：

10.1021/ja900062u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The ability of a polymer to reptate through a nanopore has an influence on its circulatory half-life and biodistribution, since many physiological barriers contain nanopores. A cyclic polymer lacks chain ends, and therefore, cyclic polymers with molecular weights greater than the renal threshold for elimination should circulate longer than their linear-polymer counterparts when injected into animals. As predicted, radiolabeled cyclic polymers with molecular weights greater than the renal threshold have longer blood circulation times in mice than do linear polymers of comparable, molecular weight.

引用

页码：3842 / +

页数：4

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