Circulating myeloid-derived suppressor cells in patients with pancreatic cancer

被引:38
|
作者
Xu, Xiao-Dong [1 ]
Hu, Jun [2 ]
Wang, Min [1 ]
Peng, Feng [1 ]
Tian, Rui [1 ]
Guo, Xing-Jun [1 ]
Xie, Yu [1 ]
Qin, Ren-Yi [1 ]
机构
[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Affiliated Tongji Hosp, Dept Biliary Pancreat Surg, Wuhan 430030, Peoples R China
[2] Tianjin Med Univ, Dept Colon Canc, Canc Inst & Hosp, Natl Clin Res Ctr Canc,Key Lab Canc Prevent & The, Tianjin 300060, Peoples R China
基金
中国国家自然科学基金;
关键词
pancreatic cancer; myeloid-derived suppressor cells; granulocyte-macrophage colony-stimulating factor; arginase; COLONY-STIMULATING FACTOR; GM-CSF; HEPATOCELLULAR-CARCINOMA; HEMATOPOIETIC CYTOKINES; SUBSETS; DIFFERENTIATION; ACCUMULATION; ACTIVATION; MECHANISM; CORRELATE;
D O I
10.1016/S1499-3872(15)60413-1
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
BACKGROUND: Myeloid-derived suppressor cells (MDSCs) are heterogeneous cell types that suppress T-cell responses in cancer patients and animal models, some MDSC subpopulations are increased in patients with pancreatic cancer. The present study was to investigate a specific subset of MDSCs in patients with pancreatic cancer and the mechanism of MDSCs increase in these patients. METHODS: Myeloid cells from whole blood were collected from 37 patients with pancreatic cancer, 17 with cholangiocarcinoma, and 47 healthy controls. Four pancreatic cancer cell lines were co-cultured with normal peripheral blood mononuclear cells (PBMCs) to test the effect of tumor cells on the conversion of PBMCs to MDSCs. Levels of granulocyte-macrophage colony-stimulating factor (GM-CSF) and arginase activity in the plasma of cancer patients were analyzed by enzyme-linked immunosorbent assay. RESULTS: CD14(+)/CD11b(+)/HLA-DR- MDSCs were increased in patients with pancreatic or bile duct cancer compared with those in healthy controls, and this increase was correlated with clinical cancer stage. Pancreatic cancer cell lines induced PBMCs to MDSCs in a dose-dependent manner. GM-CSF and arginase activity levels were significantly increased in the serum of patients with pancreatic cancer. CONCLUSIONS: MDSCs were tumor related: tumor cells induced PBMCs to MDSCs in a dose-dependent manner and circulating CD14(+)/CD11b(+)/HLA-DR- MDSCs in pancreatic cancer patients were positively correlated with tumor burden. MDSCs might be useful markers for pancreatic cancer detection and progression.
引用
收藏
页码:99 / 105
页数:7
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