A genome-wide association study of severe teenage acne in European Americans

被引：31
|
作者：
Zhang, Mingfeng [1 ,2 ]
Qureshi, Abrar A. [1 ,2 ,3 ]
Hunter, David J. [4 ]
Han, Jiali [1 ,2 ,3 ,4 ,5 ,6 ,7 ]
机构：
[1] Brigham & Womens Hosp, Dept Dermatol, Clin Res Program, Boston, MA 02115 USA
[2] Harvard Univ, Sch Med, Boston, MA USA
[3] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA 02115 USA
[4] Harvard Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02115 USA
[5] Harvard Univ, Sch Publ Hlth, Program Mol & Genet Epidemiol, Boston, MA 02115 USA
[6] Indiana Univ, Simon Canc Ctr, Dept Epidemiol, Richard M Fairbanks Sch Publ Hlth, Indianapolis, IN 46204 USA
[7] Tianjin Med Univ, Canc Inst & Hosp, Dept Epidemiol, Tianjin, Peoples R China
来源：
HUMAN GENETICS | 2014年 / 133卷 / 03期
关键词：
CANCER SUSCEPTIBILITY LOCI; PROSTATE-CANCER; ANDROGEN RECEPTOR; BREAST-CANCER; MULTIPLE LOCI; MYC EXPRESSION; IDENTIFIES; RISK; VULGARIS; POLYMORPHISM;
D O I：
10.1007/s00439-013-1374-4
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Despite the family aggregation of severe teenage acne, the genetic basis of this common skin condition remains unclear. We conducted a genome-wide association study (GWAS) on severe teenage acne in 928 European Americans. The SNP rs4133274 on chromosome 8q24 (72 kb upstream of MYC) revealed the most significant association with severe teenage acne (p value = 1.7 x 10(-6)). The variant allele of this SNP (G allele) was associated with an increased risk of severe teenage acne with odds ratio of 4.01 (95 % confidence interval = 2.37-6.82). Upon further replication, our findings suggest new genetic basis of acne and may explain the association between acne and cancer risk observed in the epidemiological studies.
引用
收藏
页码：259 / 264
页数：6
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