Propofol facilitates the development of long-term depression (LTD) and impairs the maintenance of long-term potentiation (LTP) in the CA1 region of the hippocampus of anesthetized rats

被引：86
|
作者：
Wei, HM
Xiong, WY
Yang, SC
Zhou, QX
Liang, CL
Zeng, BX
Xu, L [1 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Zool, Lab Learning & Memory, Kunming 650223, Peoples R China
[2] Huazhong Univ Technol, Anesthesiol Sect, Union Hosp, TongJi Med Coll, Wuhan, Peoples R China
[3] Kunming Gen Hosp, ChengDu Mil Area, Kunming 650223, Peoples R China
来源：
NEUROSCIENCE LETTERS | 2002年 / 324卷 / 03期
基金：
中国国家自然科学基金;
关键词：
long-term potentiation; long-term depression; memory; anesthetics; propofol; hippocampus; Wistar rat;
D O I：
10.1016/S0304-3940(02)00183-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Memory is sensitive to the short-acting anesthetic (2,6-diisopropylphenol) propofol, but the underlying mechanism is little known. Here, we have examined the effects of propofol on synaptic plasticity in the CA1 region of the hippocampus of anesthetized rats. We found that low dose of propofol (20 mg/kg, i.p.) did not affect the basal transmission, but enhanced prominently the development of long-term depression (LTD) and impaired the maintenance of long-term potentiation (LTP). The impairment of LTP maintenance and enhancement of LTD development may contribute to propofol-induced deficits in memory following propofol anesthesia. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码：181 / 184
页数：4
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