Toll-Like Receptors and Ischemic Brain Injury

被引：103

作者：

Gesuete, Raffaella ^{[1
]}

Kohama, Steven G. ^{[2
]}

Stenzel-Poore, Mary P. ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Mol Microbiol & Immunol, Portland, OR 97239 USA

[2] Oregon Natl Primate Res Ctr, Div Neurosci, Beaverton, OR USA

来源：

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY | 2014年 / 73卷 / 05期

关键词：

Cerebral ischemia; Ischemic brain injury; Preconditioning; Stroke; Toll-like receptors; PRECONDITIONING PROTECTS; CEREBRAL-ISCHEMIA; STROKE; NEUROPROTECTION; TOLL-LIKE-RECEPTOR-4; INFLAMMATION; RECOGNITION; MECHANISMS; EXPRESSION; TNF;

D O I：

10.1097/NEN.0000000000000068

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Toll-like receptors (TLRs) are master regulators of innate immunity and play an integral role in the activation of inflammatory response during infections. In addition, TLRs influence the body's response to numerous forms of injury. Recent data have shown that TLRs play a modulating role in ischemic brain damage after stroke. Interestingly, their stimulation before ischemia induces a tolerant state that is neuroprotective. This phenomenon, referred to as TLR preconditioning, is the result of the reprogramming of TLR response to ischemic injury. This review addresses the role of TLRs in brain ischemia and the activation of endogenous neuroprotective pathways in the setting of preconditioning. We highlight the protective role of interferon-related response and the potential site of action for TLR preconditioning involving the blood-brain barrier. Pharmacologic modulation of TLR activation to promote protection against stroke is a promising approach for the development of prophylactic and immediate therapies targeting ischemic brain injury.

引用

页码：378 / 386

页数：9

共 50 条

[1] Toll-like receptors and tolerance to ischemic injury
Stenzel-Poore, MP
Stevens, SL
Rosenzweig, HL
Marsh, B
Simon, RP
[J]. JOURNAL OF NEUROCHEMISTRY, 2006, 96 : 11 - 11
[2] Toll-like receptors in cerebral ischemic inflammatory injury
Yan-Chun Wang
Sen Lin
Qing-Wu Yang
[J]. Journal of Neuroinflammation, 8
[3] Toll-like receptors in cerebral ischemic inflammatory injury
Wang, Yan-Chun
Lin, Sen
Yang, Qing-Wu
[J]. JOURNAL OF NEUROINFLAMMATION, 2011, 8
[4] Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits
Tang, Sung-Chun
Arumugam, Thiruma V.
Xu, Xiangru
Cheng, Aiwu
Mughal, Mohamed R.
Jo, Dong Gyu
Lathia, Justin D.
Siler, Dominic A.
Chigurupati, Srinivasulu
Ouyang, Xin
Magnus, Tim
Camandola, Simonetta
Mattson, Mark P.
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2007, 104 (34) : 13798 - 13803
[5] The Role of Toll-like Receptors in Perinatal Brain Injury
Mallard, Carina
Wang, Xiaoyang
Hagberg, Henrik
[J]. CLINICS IN PERINATOLOGY, 2009, 36 (04) : 763 - +
[6] Toll-like receptors and tolerance to ischaemic injury in the brain
Stevens, S. L.
Stenzel-Poore, M. P.
[J]. BIOCHEMICAL SOCIETY TRANSACTIONS, 2006, 34 : 1352 - 1355
[7] Toll-like Receptors and Cardiac Injury
Wei, C.
[J]. CARDIOLOGY, 2009, 114 : 85 - 85
[8] Toll-Like Receptors in Brain Abscess
Esen, Nilufer
Kielian, Tammy
[J]. TOLL-LIKE RECEPTORS: ROLES IN INFECTION AND NEUROPATHOLOGY, 2009, 336 : 41 - 61
[9] Toll-Like Receptors, Tissue Injury, and Tumourigenesis
Ioannou, Savvas
Voulgarelis, Michael
[J]. MEDIATORS OF INFLAMMATION, 2010, 2010
[10] Toll-Like Receptors in Spinal Cord Injury
Kigerl, Kristina A.
Popovich, Phillip G.
[J]. TOLL-LIKE RECEPTORS: ROLES IN INFECTION AND NEUROPATHOLOGY, 2009, 336 : 121 - 136

← 1 2 3 4 5 →