Carbonic anhydrase IX: A promising diagnostic and prognostic biomarker in breast carcinoma
被引:6
|
作者:
Furjelova, Martina
论文数: 0引用数: 0
h-index: 0
机构:
Comenius Univ, Dept Histol & Embryol, Jessenius Fac Med, Martin 03601, SlovakiaComenius Univ, Dept Histol & Embryol, Jessenius Fac Med, Martin 03601, Slovakia
Furjelova, Martina
[1
]
Kovalska, Maria
论文数: 0引用数: 0
h-index: 0
机构:
Comenius Univ, Dept Histol & Embryol, Jessenius Fac Med, Martin 03601, SlovakiaComenius Univ, Dept Histol & Embryol, Jessenius Fac Med, Martin 03601, Slovakia
Kovalska, Maria
[1
]
Jurkova, Katarina
论文数: 0引用数: 0
h-index: 0
机构:
Comenius Univ, Dept Histol & Embryol, Jessenius Fac Med, Martin 03601, Slovakia
Comenius Univ, Dept Med Biochem, Jessenius Fac Med, Martin 03601, SlovakiaComenius Univ, Dept Histol & Embryol, Jessenius Fac Med, Martin 03601, Slovakia
Jurkova, Katarina
[1
,3
]
Horacek, Jaroslav
论文数: 0引用数: 0
h-index: 0
机构:
Univ Ostrava, Fac Med, Dept Pathol, Ostrava 70300, Czech RepublicComenius Univ, Dept Histol & Embryol, Jessenius Fac Med, Martin 03601, Slovakia
Horacek, Jaroslav
[2
]
Carbolova, Tereza
论文数: 0引用数: 0
h-index: 0
机构:
Univ Ostrava, Fac Med, Dept Histol & Embryol, Ostrava 70300, Czech RepublicComenius Univ, Dept Histol & Embryol, Jessenius Fac Med, Martin 03601, Slovakia
Carbolova, Tereza
[4
]
Adamkov, Marian
论文数: 0引用数: 0
h-index: 0
机构:
Comenius Univ, Dept Histol & Embryol, Jessenius Fac Med, Martin 03601, SlovakiaComenius Univ, Dept Histol & Embryol, Jessenius Fac Med, Martin 03601, Slovakia
Adamkov, Marian
[1
]
机构:
[1] Comenius Univ, Dept Histol & Embryol, Jessenius Fac Med, Martin 03601, Slovakia
We examined the expression of carbonic anhydrase IX (CA IX) by immunohistochemical staining using monoclonal antibody M75 (Institute of Virology, Slovak Academy of Sciences, Bratislava) in a group of 38 fibroadenomas and 55 carcinomas of the breast. In each case, the intensity of staining, percentage of labeled cells and subcellular localization of CA IX were assessed. CA IX was detected in 11/38 fibroadenomas (28.9%). Weak cytoplasmic positivity was dominant in these positive cases. Immunohistochemical analysis of 55 carcinomas showed CA IX expression in 34 cases (61.8%). Membrane staining alone was observed in 27/55 carcinomas (49.1%), while cytoplasmic positivity was found in 4/55 cases (7.3%). Combined membrane and cytoplasmic immunostaining of CA IX was detected in 3/55 carcinomas (5.4%). The intensity of immunoreactivity varied from weak to strong. Under 50% of reactive cells were found in 9/38 fibroadenomas (23.6%) and in 29/55 carcinomas (52.7%). More than 50% of reactive cells were found in 2/38 fibroadenomas (5.3%) and in 5/55 carcinomas (9.1%). Statistical analysis confirmed significant differences in the subcellular localization, intensity of immunoreactivity and percentage of labeled cells in fibroadenomas and carcinomas (p < 0.05). Our results confirmed the hypothesis that expression of CA IX may represent a valuable tumor biomarker as well as a promising diagnostic and prognostic parameter in breast cancer. (C) 2013 Elsevier GmbH. All rights reserved.
机构:
Recep Tayyip Erdogan Univ, Fac Med, Div Med Oncol, Dept Internal Med, TR-53200 Rize, TurkeyRecep Tayyip Erdogan Univ, Fac Med, Div Med Oncol, Dept Internal Med, TR-53200 Rize, Turkey
Cetin, Bulent
Gonul, Ipek Isik
论文数: 0引用数: 0
h-index: 0
机构:
Gazi Univ, Fac Med, Dept Pathol, Div Med Oncol, Ankara, TurkeyRecep Tayyip Erdogan Univ, Fac Med, Div Med Oncol, Dept Internal Med, TR-53200 Rize, Turkey
Gonul, Ipek Isik
Gumusay, Ozge
论文数: 0引用数: 0
h-index: 0
机构:
Gaziosmanpasa Univ, Fac Med, Div Med Oncol, Dept Internal Med, Tokat, TurkeyRecep Tayyip Erdogan Univ, Fac Med, Div Med Oncol, Dept Internal Med, TR-53200 Rize, Turkey
Gumusay, Ozge
Bilgetekin, Irem
论文数: 0引用数: 0
h-index: 0
机构:
Dr AY Ankara Oncol Training & Res Hosp, Div Med Oncol, Dept Internal Med, Ankara, TurkeyRecep Tayyip Erdogan Univ, Fac Med, Div Med Oncol, Dept Internal Med, TR-53200 Rize, Turkey
Bilgetekin, Irem
Algin, Efnan
论文数: 0引用数: 0
h-index: 0
机构:
Ankara Numune Training & Res Hosp, Div Med Oncol, Dept Internal Med, Ankara, TurkeyRecep Tayyip Erdogan Univ, Fac Med, Div Med Oncol, Dept Internal Med, TR-53200 Rize, Turkey
Algin, Efnan
Ozet, Ahmet
论文数: 0引用数: 0
h-index: 0
机构:
Gazi Univ, Div Med Oncol, Fac Med, Dept Internal Med, Ankara, TurkeyRecep Tayyip Erdogan Univ, Fac Med, Div Med Oncol, Dept Internal Med, TR-53200 Rize, Turkey
Ozet, Ahmet
Uner, Aytug
论文数: 0引用数: 0
h-index: 0
机构:
Gazi Univ, Div Med Oncol, Fac Med, Dept Internal Med, Ankara, TurkeyRecep Tayyip Erdogan Univ, Fac Med, Div Med Oncol, Dept Internal Med, TR-53200 Rize, Turkey
机构:
Univ Calif Los Angeles, Dept Urol, David Geffen Sch Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Urol, David Geffen Sch Med, Los Angeles, CA 90095 USA
Klatte, Tobias
Seligson, David B.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Urol, David Geffen Sch Med, Los Angeles, CA 90095 USA
Seligson, David B.
Rao, Jian Yu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Urol, David Geffen Sch Med, Los Angeles, CA 90095 USA
Rao, Jian Yu
Yu, Hong
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Pathol & Lab Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Urol, David Geffen Sch Med, Los Angeles, CA 90095 USA
Yu, Hong
de Martino, Michela
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Urol, David Geffen Sch Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Urol, David Geffen Sch Med, Los Angeles, CA 90095 USA
de Martino, Michela
Kawaoka, Kelly
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Urol, David Geffen Sch Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Urol, David Geffen Sch Med, Los Angeles, CA 90095 USA
Kawaoka, Kelly
Wong, Steven G.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, David Geffen Sch Med, Dept Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Urol, David Geffen Sch Med, Los Angeles, CA 90095 USA
Wong, Steven G.
Belldegrun, Arie S.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Urol, David Geffen Sch Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Urol, David Geffen Sch Med, Los Angeles, CA 90095 USA
Belldegrun, Arie S.
Pantuck, Allan J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Los Angeles, Dept Urol, David Geffen Sch Med, Los Angeles, CA 90095 USAUniv Calif Los Angeles, Dept Urol, David Geffen Sch Med, Los Angeles, CA 90095 USA