CD4 T cell responses to influenza infection

被引：120
|
作者：
Brown, DM [1 ]
Román, E [1 ]
Swain, SL [1 ]
机构：
[1] Trudeau Inst Inc, Saranac Lake, NY 12983 USA
来源：
SEMINARS IN IMMUNOLOGY | 2004年 / 16卷 / 03期
关键词：
CD4 T cells; influenza; IFN-gamma; memory T cells; cytotoxicity;
D O I：
10.1016/j.smim.2004.02.004
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Immune responses to viral infections involve a complex orchestration between innate signals and adaptive responses of specific T and B cells. Anti-viral CD4 cells can direct CD8 responses by secreting a Type 1 panel of cytokines including IFN-gamma, IL-2 and TNF-alpha and can drive B cell production of IgG2a to neutralize infective viral particles. This review will focus specifically on the role of CD4 cells in the immune response to influenza, an acute, localized respiratory viral infection. We suggest that CD4 cells act as direct effectors in protection against influenza, may contribute to immunopathology and generate functionally distinct memory subsets. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：171 / 177
页数：7
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