Comparison of Labial Minor Salivary Gland Biopsies from Childhood Sjogren Syndrome and Age-matched Controls

被引:21
|
作者
Yokogawa, Naoto [1 ]
Lieberman, Scott M. [2 ]
Alawi, Faizan [3 ]
Bout-Tabaku, Sharon [5 ,6 ]
Guttenberg, Marta [7 ]
Sherry, David D. [8 ]
Vivino, Frederick B. [4 ]
机构
[1] Tokyo Metropolitan Tama Med Ctr, Dept Rheumat Dis, Tokyo, Japan
[2] Univ Iowa, Carver Coll Med, Stead Family Dept Pediat, Div Rheumatol, Iowa City, IA 52242 USA
[3] Univ Penn, Dept Dermatol, Div Dermatopathol, Philadelphia, PA 19104 USA
[4] Univ Penn, Div Rheumatol, Philadelphia, PA 19104 USA
[5] Ohio State Univ, Coll Med, Div Rheumatol, Nationwide Childrens Hosp, Columbus, OH 43210 USA
[6] Ohio State Univ, Coll Med, Dept Pediat, Columbus, OH 43210 USA
[7] Childrens Hosp Philadelphia, Div Anat Pathol, Philadelphia, PA 19104 USA
[8] Childrens Hosp Philadelphia, Div Rheumatol, Philadelphia, PA 19104 USA
关键词
SJOGREN SYNDROME; PEDIATRICS; DIAGNOSIS; MINOR SALIVARY GLANDS; PATHOLOGY; CLASSIFICATION CRITERIA; ADOLESCENTS; FEATURES; CHILDREN;
D O I
10.3899/jrheum.131511
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To determine an appropriate focus score cutoff for childhood Sjogren syndrome (SS). Methods. Labial salivary gland tissue from specimens from children with SS and age-matched controls was retrospectively identified and reviewed by a blinded oral pathologist. Results. The presence of any focal sialadenitis (focus score > 0 foci/4 mm(2)) was common among childhood SS samples but present in only 1 of 8 control samples. Conclusion. The presence of any focal lymphocytic sialadenitis in minor labial salivary gland tissue is suggestive of childhood SS and should be included in future childhood SS-specific diagnostic or classification criteria.
引用
收藏
页码:1178 / 1182
页数:5
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