Pd(II)-Catalyzed Enantioselective C(sp3)-H Arylation of Free Carboxylic Acids

被引：117

作者：

Shen, Peng-Xiang ^{[1
]}

Hu, Liang ^{[1
]}

Shao, Qan ^{[1
]}

Hong, Kai ^{[1
]}

Yu, Jin-Quan ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, 10550 N Torrey Pines Rd, La Jolla, CA 92037 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2018年 / 140卷 / 21期

关键词：

C-H ARYLATION; BETA-C(SP(3))-H ARYLATION; AMINO-ACIDS; ACTIVATION; BONDS; FUNCTIONALIZATION; CYCLOPROPANATION; INDOLINES;

D O I：

10.1021/jacs.8b03509

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A monoprotected aminoethyl amine chiral ligand based on an ethylenediamine backbone was developed to achieve Pd-catalyzed enantioselective C(sp(3))-H arylation of cyclopropanecarboxylic and 2-aminoisobutyric acids without using exogenous directing groups. This new chiral catalyst affords new disconnection for preparing diverse chiral carboxylic acids from simple starting materials that are complementary to the various ring forming approaches.

引用

页码：6545 / 6549

页数：5

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