Clinical Utility of Fecal Biomarkers for the Diagnosis and Management of Inflammatory Bowel Disease

被引：136
|
作者：
Kopylov, Uri [1 ,2 ]
Rosenfeld, Greg [3 ]
Bressler, Brian [3 ]
Seidman, Ernest [1 ,2 ]
机构：
[1] McGill Univ, Ctr Hlth, Div Gastroenterol, Montreal, PQ, Canada
[2] McGill Univ, Dept Med, Montreal, PQ, Canada
[3] Univ British Columbia, Dept Med, Div Gastroenterol, Vancouver, BC, Canada
来源：
INFLAMMATORY BOWEL DISEASES | 2014年 / 20卷 / 04期
关键词：
Crohn's disease; ulcerative colitis; fecal biomarkers; fecal calprotectin; lactoferrin; C-reactive protein; C-REACTIVE PROTEIN; NEUTROPHIL-DERIVED PROTEINS; SEVERE ULCERATIVE-COLITIS; ILEAL POUCH INFLAMMATION; CROHNS-DISEASE; INTESTINAL INFLAMMATION; SURROGATE MARKERS; BLOOD LEUKOCYTES; GASTROINTESTINAL SYMPTOMS; ENDOSCOPIC ACTIVITY;
D O I：
10.1097/01.MIB.0000442681.85545.31
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Diagnosis and monitoring of inflammatory bowel diseases rely on clinical, endoscopic, and radiologic parameters. Inflammatory biomarkers have been investigated as a surrogate marker for endoscopic diagnosis of inflammatory activity. Fecal inflammatory biomarkers such as calprotectin and lactoferrin are direct products of bowel inflammation and provide an accurate and noninvasive diagnostic and monitoring modality for Crohn's disease and ulcerative colitis. This report contains an overview of the currently existing literature pertaining to clinical implications of fecal biomarkers for diagnosis, monitoring, and prediction of outcomes of inflammatory bowel disease.
引用
收藏
页码：742 / 756
页数：15
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