An Ancient Family of RNA-Binding Proteins: Still Important!

被引：49
|
作者：
Wells, Melissa L. [1 ]
Perera, Lalith [2 ]
Blackshear, Perry J. [1 ,3 ,4 ]
机构：
[1] NIEHS, Signal Transduct Lab, POB 12233, Res Triangle Pk, NC 27709 USA
[2] NIEHS, Genome Integr & Struct Biol Lab, POB 12233, Res Triangle Pk, NC 27709 USA
[3] Duke Univ, Dept Biochem, Med Ctr, Durham, NC 27710 USA
[4] Duke Univ, Dept Med, Med Ctr, Durham, NC 27710 USA
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2017年 / 42卷 / 04期
基金：
美国国家卫生研究院;
关键词：
ZINC-FINGER PROTEINS; TRISTETRAPROLIN-DEFICIENCY SYNDROME; GENOME-WIDE ANALYSIS; FACTOR MESSENGER-RNA; AU-RICH ELEMENT; POSTTRANSCRIPTIONAL REGULATION; SCHIZOSACCHAROMYCES-POMBE; TNF-ALPHA; CELL; RECRUITMENT;
D O I：
10.1016/j.tibs.2016.12.003
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
RNA-binding proteins are important modulators of mRNA stability, a crucial process that determines the ultimate cellular levels of mRNAs and their encoded proteins. The tristetraprolin (TTP) family of RNA-binding proteins appeared early in the evolution of eukaryotes, and has persisted in modern eukaryotes. The domain structures and biochemical functions of family members from widely divergent lineages are remarkably similar, but their mRNA 'targets' can be very different, even in closely related species. Recent gene knockout studies in species as distantly related as plants, flies, yeasts, and mice have demonstrated crucial roles for these proteins in a wide variety of physiological processes. Inflammatory and hematopoietic phenotypes in mice have suggested potential therapeutic approaches for analogous human disorders.
引用
收藏
页码：285 / 296
页数：12
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