Synthesis of a new polycyclic heterocyclic ring system. Part III. Benzo[b] imidazo[1,5-d][1,4] oxazepine-1,4(2H, 5H)-diones

被引：3

作者：

Stanisheva, Desislava V. ^{[1
]}

Gerova, Mariana S. ^{[1
]}

Petrov, Ognyan I. ^{[1
]}

机构：

[1] Sofia Univ St Kliment Ohridski, Fac Chem & Pharm, Dept Pharmaceut & Appl Organ Chem, 1 James Bourchier Blvd, Sofia 1164, Bulgaria

来源：

HETEROCYCLIC COMMUNICATIONS | 2017年 / 23卷 / 01期

关键词：

benzoxazepine; benzoxazole; heterocycle; imi-dazole; ring transformation; BENZOXAZEPINE; DERIVATIVES;

D O I：

10.1515/hc-2016-0236

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of novel tricyclic benzoxazepines with fused imidazolone ring was prepared in five steps start-ing from the corresponding benzoxazolones 1-3. The key to the reported synthetic approach is transformation of 3-(2-oxopropyl)-2(3H)-benzoxazolones 4-6 to 1-(2-hydroxyphenyl)-4-methyl-1,3-dihydro-2H--imidazol-2- ones 7-12, and their subsequent conversion to the phenoxy-acetic acids 19-24, which were finally acylated in polyphosphoric acid to form the oxazepine ring.

引用

页码：23 / 27

页数：5

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