Role of the Antioxidant Activity of Melatonin in Myocardial Ischemia-Reperfusion Injury

被引：18

作者：

Bermudez-Gonzalez, Jorge Luis ^{[1
,2
]}

Sanchez-Quintero, Denya ^{[2
]}

Proano-Bernal, Leonardo ^{[2
]}

Santana-Apreza, Rafael ^{[2
]}

Jimenez-Chavarria, Marco Antonio ^{[2
]}

Luna-Alvarez-Amezquita, Jose Antonio ^{[1
]}

Straface, Juan Ignacio ^{[1
]}

Perez-Partida, Arantza Marie ^{[1
]}

Berarducci, Joaquin ^{[1
]}

Armenta-Moreno, Javier Ivan ^{[1
]}

Garza-Cruz, Karla Joana ^{[1
]}

Espinola-Zavaleta, Nilda ^{[1
]}

Alexanderson-Rosas, Erick ^{[1
,2
]}

机构：

[1] Natl Inst Cardiol Ignacio Chavez, Juan Badiano 1,Belisario Dominguez Secc 16, Mexico City 14080, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Copilco Univ, Fac Med, Escolar 411 A,Copilco Univ, Mexico City 04360, DF, Mexico

来源：

ANTIOXIDANTS | 2022年 / 11卷 / 04期

关键词：

melatonin; ischemia-reperfusion; coronary artery disease; circadian rhythms; animal model; myocardial infarction; PERCUTANEOUS CORONARY INTERVENTION; RECEPTOR SUBTYPE; BINDING-SITE; PROTECTS; ATHEROSCLEROSIS; EXPRESSION; INFARCTION; MECHANISM; REDUCE; ARTERY;

D O I：

10.3390/antiox11040627

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ischemia-reperfusion injury is a common problem in the age of interventional cardiology; it is primarily mediated by oxidative stress and reactive agents. Melatonin has antioxidative properties that make its use promising for treating ischemia-reperfusion injury. Multiple experimental studies in murine and porcine models have been performed with good results. Clinical trials have also been conducted but given their heterogeneity, no conclusive results can be made. Melatonin pharmacokinetic properties are not ideal; therefore, many analogs have been proposed with improved characteristics, and some studies have evaluated their efficacy in animal models, but clinical trials are needed to recommend their use. In this review, we expose the results of the most impactful studies regarding melatonin use in ischemia-reperfusion injury.

引用

页数：21

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