Total synthesis of the isoquinoline alkaloid decumbenine B via Ru(III)-catalyzed C-H activation

被引：16

作者：

Zhang, Yong ^{[1
]}

Yang, Zhongzhen ^{[1
]}

Guo, Lingmei ^{[1
]}

Li, Weijian ^{[1
]}

Cheng, Xu ^{[1
]}

Wang, Xiaolong ^{[1
]}

Wang, Qiantao ^{[1
]}

Hai, Li ^{[1
]}

Wu, Yong ^{[1
]}

机构：

[1] Sichuan Univ, West China Sch Pharm, Dept Med Chem, Educ Minist,Key Lab Drug Targeting & Drug Deliver, 17 3rd Sect,South Renmin Rd, Chengdu 610041, Sichuan, Peoples R China

来源：

ORGANIC CHEMISTRY FRONTIERS | 2018年 / 5卷 / 10期

基金：

中国国家自然科学基金;

关键词：

DIRECT HYDROXYMETHYLATION; CYCLIZATION; AMIDATION; PYRIDINES;

D O I：

10.1039/c8qo00193f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel and efficient method for the total synthesis of the natural product decumbenine B was described. The shortcomings in the existing synthetic routes of this isoquinoline alkaloid were minimized through the application of Ru(III)-catalyzed direct ortho-hydroxymethylation of intermediate 9. With this method, decumbenine B could be easily synthesized from commercially available materials by only five steps with an overall yield of 26.1%.

引用

页码：1604 / 1607

页数：4

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