A new PET resolution measurement method through Monte-Carlo simulations

Objective The aim of this study was to propose a novel method for image quality assessment in PET scanners through estimation of the modulation transfer function (MTF) of a plane source. The simulation was implemented using the previously validated Monte-Carlo model. A comparison of the proposed method with the more traditional technique, based on a line source, was also performed. Materials and methods The Geant4 application for tomographic emission (GATE) Monte-Carlo package was used for model development, and reconstructed images were obtained using software for tomographic image reconstruction (STIR) with cluster computing. A novel plane source consisting of a radioactive (F-18-fluorodeoxyglucose) thin-layer chromatography plate was simulated (total source activity: 44.4MBq) to assess image quality through the MTF. All images were reconstructed with the three-dimensional filtered back projection (FBP3DRP) and ordered-subsets expectation maximization (OSEM) reprojection algorithms. Results The MTFs obtained using ordered-subsets expectation maximization show, in all cases, that higher frequencies are preserved compared with those obtained using the FBP3DRP. In addition, the plane source method is less prone to noise than the conventional line source method (SD = 0.0031 and 0.0203, respectively). Conclusion The thin-layer chromatography-based plane source presented requires materials commonly found in a clinical environment and could be used to assess image quality in nuclear medicine departments and to further develop PET and single-photon emission computed tomography scanners through Monte-Carlo simulations. (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.