The Effect of Polysaccharide K with S-1 Based Chemotherapy in Advanced Gastric Cancer

被引：5
|
作者：
Yoshikawa, Kozo [1 ]
Shimada, Mitsuo [1 ]
Kurita, Nobuhiro [1 ]
Sato, Hirohiko [1 ]
Iwata, Takashi [1 ]
Nishioka, Masanori [1 ]
Morimoto, Shinya [1 ]
Miyatani, Tomohiko [1 ]
Komatsu, Masato [1 ]
Kashihara, Hideya [1 ]
Takasu, Chie [1 ]
机构：
[1] Univ Tokushima, Dept Surg, Tokushima 770, Japan
来源：
HEPATO-GASTROENTEROLOGY | 2013年 / 60卷 / 126期
基金：
日本学术振兴会;
关键词：
Polysaccharide K; Advanced gastric cancer; Foxp3; REGULATORY T-CELLS; III COLORECTAL-CANCER; ADJUVANT IMMUNOCHEMOTHERAPY; STAGE-II; TEGAFUR/URACIL; EFFICACY; PSK;
D O I：
10.5754/hge11355
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Background/Aims: Polysaccharide K (PSK) is widely used in Japan as a biological response modifier for cancer patients. We investigated the effects of PSK with S-1 based chemotherapy for advanced gastric cancer patients in immune response. Methodology: Nine advanced gastric cancer patients who underwent chemotherapy at the University of Tokushima were included in this study. In all patients, 3g PSK was received orally and S-1 based chemotherapy for 2 weeks alternately for 8 weeks. Serial changes in immunological parameters (Foxp3, Natural killer (NK), CD4/CD8) were monitored. Results: The levels of Foxp3 at 8 weeks was significantly decreased compared with 2 weeks (4.26% vs. 3.11%). In NK activity at 8 weeks was significantly increased compared with 2 weeks (27% vs. 47%). Conclusions: These results of this study suggested that chemotherapy with PSK improved the immune response in advanced gastric cancer patients. Especially Foxp3 was concerned in this mechanism.
引用
收藏
页码：1387 / 1390
页数：4
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