Effects of fluoxetine on locomotor activity: Possible involvement of dopamine

被引：0
|
作者：
Shishkina, G. T. [1 ]
Yudina, A. M. [1 ]
Dygalo, N. N. [1 ]
机构：
[1] Russian Acad Sci, Siberian Div, Inst Cytol & Genet, Novosibirsk, Russia
来源：
ZHURNAL VYSSHEI NERVNOI DEYATELNOSTI IMENI I P PAVLOVA | 2006年 / 56卷 / 04期
关键词：
fluoxetine; anxiety; locomotor activity; 5-hydroxyindoleacetic acid; dopamine;
D O I：
暂无
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Plus-maze benavior of adult mail rats was assessed and contents of 5-hydroxyindoleacetic acid (5-HIAA) and dopamine (DA) in different brain regions were analyzed after two-week fluoxetine treatment (25 mg/kg/day, per os). Chronic fluoxetine treatment produced a general decrease in the brain 5-HIAA content and a decrease in DA content in the frontal cortex and striatum. Behaviorally, fluoxetine-treated animals displayed enhanced anxiety and decreased locomotor activity. The DA depletion os supposed to be responsible for fluoxetine-produced hypolocomotion. This is supported by a significant correlation between the dopamine content in the frontal cortex and the number of entries into the closed arms of the plus-maze. The results suggest that the hypolocomotor effect of fluoxetine may involve the changes in the dopaminergic system.
引用
收藏
页码：523 / 528
页数：6
相关论文
共 50 条
  • [1] Fluoxetine effects on sheepshead minnow (Cyprinodon variegatus) locomotor activity
    Winder, Virginia L.
    Pennington, Paul L.
    Hurd, Mark W.
    Wirth, Ed F.
    [J]. JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART B-PESTICIDES FOOD CONTAMINANTS AND AGRICULTURAL WASTES, 2012, 47 (01) : 51 - 58
  • [2] Fluoxetine, but not sertraline or citalopram, potentiates the locomotor stimulant effect of cocaine: possible pharmacokinetic effects
    Fletcher, PJ
    Sinyard, J
    Salsali, M
    Baker, GB
    [J]. PSYCHOPHARMACOLOGY, 2004, 174 (03) : 406 - 413
  • [3] Fluoxetine, but not sertraline or citalopram, potentiates the locomotor stimulant effect of cocaine: possible pharmacokinetic effects
    Paul J. Fletcher
    Judy Sinyard
    Mahnaz Salsali
    Glen B. Baker
    [J]. Psychopharmacology, 2004, 174 : 406 - 413
  • [4] The involvement of cerebellar dopamine D3 receptors in locomotor activity of rats
    W. Kolasiewicz
    J. Maj
    K. Ossowska
    [J]. Journal of Neural Transmission, 2008, 115 : 677 - 681
  • [5] The involvement of cerebellar dopamine D3 receptors in locomotor activity of rats
    Kolasiewicz, W.
    Maj, J.
    Ossowska, K.
    [J]. JOURNAL OF NEURAL TRANSMISSION, 2008, 115 (05) : 677 - 681
  • [6] EFFECTS OF MORPHINE ON STRIATAL DOPAMINE METABOLISM - POSSIBLE MECHANISM OF ITS OPPOSITE EFFECT ON LOCOMOTOR ACTIVITY IN RATS AND MICE
    KUSCHINSKY, K
    HORNYKIEWICZ, O
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1974, 26 (01) : 41 - 50
  • [7] Cannabinoid and dopamine interaction in rodent brain: effects on locomotor activity
    Meschler, JP
    Conley, TJ
    Howlett, AC
    [J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2000, 67 (03) : 567 - 573
  • [8] Involvement of adenosine A2A and dopamine receptors in the locomotor and sensitizing effects of cocaine
    Filip, M
    Frankowska, M
    Zaniewska, M
    Przegalinski, E
    Muller, CE
    Agnati, L
    Franco, R
    Roberts, DCS
    Fuxe, K
    [J]. BRAIN RESEARCH, 2006, 1077 : 67 - 80
  • [9] Involvement of serotonin and dopamine receptors in immobility effects of fluoxetine in the forced swimming test.
    Sugimoto, Y
    Yamada, J
    [J]. JOURNAL OF PHARMACOLOGICAL SCIENCES, 2003, 91 : 200P - 200P
  • [10] Effects of dopamine agonists and antagonists on locomotor activity in male and female rats
    Schindler, CW
    Cannona, GN
    [J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 2002, 72 (04) : 857 - 863
12345