A generalized Michaelis-Menten response surface

被引:0
|
作者
Hirst, K
Zerbe, GO
Hay, WW
机构
[1] HENRY FORD HLTH SCI CTR, DIV BIOSTAT & RES EPIDEMIOL, 1 FORD PL, 3E, DETROIT, MI 48202 USA
[2] UNIV COLORADO, HLTH SCI CTR, DEPT PREVENT MED & BIOMETR, DENVER, CO 80262 USA
[3] UNIV COLORADO, HLTH SCI CTR, DEPT PEDIAT, DENVER, CO 80262 USA
关键词
D O I
10.1002/(SICI)1097-0258(19961015)15:19<2107::AID-SIM338>3.3.CO;2-T
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
We describe an application of recently developed generalized Michaelis-Menten response surface and non-linear mixed model methodologies to model glucose utilization in foetal sheep, More specifically, we model the response surface of glucose utilization rate in the foetal sheep as a function of glucose and insulin concentrations using a three-dimensional analogue of the Michaelis-Menten pharmacokinetic model. To account for multiple measurements per sheep, we apply the non-linear mixed effects model proposed by Lindstrom and Bates using the EM algorithm computational scheme presented by Hirst et al.
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页码:2107 / 2119
页数:13
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