Sample size estimation for the van Elteren test - a stratified Wilcoxon-Mann-Whitney test

被引:18
|
作者
Zhao, Yan D. [1 ]
机构
[1] Eli Lilly & Co, Lilly Res Labs, Indianapolis, IN 46285 USA
关键词
sample size estimation; van Elteren test; non-parametric; Wilcoxon-Mann-Whitney test; stratified test;
D O I
10.1002/sim.2441
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
The van Elteren test is a type of stratified Wilcoxon-Mann-Whitney test for comparing two treatments accounting for strata. In this paper, we study sample size estimation methods for the asymptotic version of the van Elteren test, assuming that the stratum fractions (ratios of each stratum size to the total sample size) and the treatment fractions (ratios of each treatment size to the stratum size) are known in the study design. In particular, we develop three large-sample sample size estimation methods and present a real data example to illustrate the necessary information in the study design phase in order to apply the methods. Simulation studies are conducted to compare the performance of the methods and recommendations are made for method choice. Finally, sample size estimation for the van Elteren test when the stratum fractions are unknown is also discussed. Copyright (c) 2005 John Wiley & Sons, Ltd.
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页码:2675 / 2687
页数:13
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