Transcription-based drug repurposing for COVID-19

被引：4
|
作者：
Killick, Richard [1 ]
Ballard, Clive [2 ]
Doherty, Patrick [3 ]
Williams, Gareth [3 ]
机构：
[1] Kings Coll London, Maurice Wohl Clin Neurosci Inst, London, England
[2] Univ Exeter, Med Sch, Coll Med & Hlth, Exeter, Devon, England
[3] Kings Coll London, Wolfson Ctr Age Related Dis, London, England
来源：
VIRUS RESEARCH | 2020年 / 290卷
关键词：
COVID-19; Gene expression; Repurposing; CONNECTIVITY MAP; K+-ATPASE; EXPRESSION; DISCOVERY; RECEPTOR; NA+;
D O I：
10.1016/j.virusres.2020.198176
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We have utilised the transcriptional response of lung epithelial cells following infection by the original Severe Acute Respiratory Syndrome coronavirus (SARS) to identify repurposable drugs for COVID-19. Drugs best able to recapitulate the infection profile are highly enriched for antiviral activity. Nine of these have been tested against SARS-2 and found to potently antagonise SARS-2 infection/replication, with a number now being considered for clinical trials. It is hoped that this approach may serve to broaden the spectrum of approved drugs that should be further assessed as potential anti-COVID-19 agents and may help elucidate how this seemingly disparate collection of drugs are able to inhibit SARS-2 infection/replication.
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页数：3
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