Hepatotoxicity of tricyclazole in zebrafish (Danio rerio)

被引：63

作者：

Qiu, Lingyu ^{[1
,2
]}

Jia, Kun ^{[1
,2
,3
]}

Huang, Lirong ^{[1
,2
,3
]}

Liao, Xinjun ^{[1
,2
,3
]}

Guo, Xinchun ^{[4
]}

Lu, Huiqiang ^{[1
,2
,3
]}

机构：

[1] Jiangxi Engn Lab Zebrafish Modeling & Drug Screen, Jian, Jiangxi, Peoples R China

[2] Jiangxi Key Lab Dev Biol Organs, Jian, Jiangxi, Peoples R China

[3] Jinggangshan Univ, Coll Life Sci, Ctr Dev Biol, Jian, Jiangxi, Peoples R China

[4] Gannan Normal Univ, Sch Geog & Environm Engn, Ganzhou, Jiangxi, Peoples R China

来源：

CHEMOSPHERE | 2019年 / 232卷

基金：

中国国家自然科学基金;

关键词：

Tricyclazole; Hepatotoxicity; Oxidative stress; Metabolism disorder; Zebrafish; CONSTITUTIVE ANDROSTANE RECEPTOR; DEVELOPMENTAL TOXICITY; LIVER HYPERTROPHY; MOUSE-LIVER; MODEL; INVOLVEMENT; ACTIVATION; PESTICIDES; TOXICOLOGY; APOPTOSIS;

D O I：

10.1016/j.chemosphere.2019.05.159

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Tricyclazole is widely used in agriculture as a pesticide, but its toxicity in vertebrates is currently poorly evaluated. In this study, we used zebrafish to assess the toxicity of tricyclazole. We found that tricyclazole induces liver damage, or hepatotoxicity, in zebrafish, during both development and adulthood. In embryos, we found that tricyclazole affected the liver development rather than other endodermal tissues such as gut and pancreas. In both embryos and adult zebrafish livers, tricyclazole disrupted the relationship between oxidant and antioxidant system and resulted in reactive oxygen species (ROS) overload. Meanwhile, it triggered hepatocyte apoptosis and disturbed carbohydrate/lipid metabolism and energy demand systems. These results suggested that tricyclazole could cause severe consequences for vertebrate hepatic development and function. (C) 2019 Elsevier Ltd. All rights reserved.

引用

页码：171 / 179

页数：9

共 50 条

[1] Interacted toxic mechanisms of ochratoxin A and tricyclazole on the zebrafish (Danio rerio)
Wang Y.
Deng M.
Chen C.
Lv L.
Zhu H.
Chen L.
Weng H.
[J]. Chemosphere, 2023, 326
[2] Assessing the hepatotoxicity of phosphogypsum leachate in zebrafish (Danio rerio)
Wang, Min
Guo, Ziyu
Du, Jiangfeng
Lu, Hongliang
Liu, Long
Wang, Tao
Pan, Sha
[J]. Science of the Total Environment, 926
[3] Assessing the hepatotoxicity of phosphogypsum leachate in zebrafish ( Danio rerio )
Wang, Min
Guo, Ziyu
Du, Jiangfeng
Lu, Hongliang
Liu, Long
Wang, Tao
Pan, Sha
[J]. SCIENCE OF THE TOTAL ENVIRONMENT, 2024, 926
[4] Physiological effects of tricyclazole on zebrafish (Danio rerio) and post-exposure recovery
Sancho, Encarna
Fernandez-Vega, Cristina
Jose Villarroel, Ma
Andreu-Moliner, Enrique
Dolores Ferrando, Ma
[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY, 2009, 150 (01): : 25 - 32
[5] Bixafen causes hepatotoxicity and pancreas toxicity in zebrafish (Danio rerio)
Yini Wang
Huihan Peng
Hailing Yu
[J]. Ecotoxicology, 2023, 32 : 837 - 844
[6] Does hepatotoxicity interfere with endocrine activity in zebrafish (Danio rerio)?
Baumann, Lisa
Holbech, Henrik
Schmidt-Posthaus, Heike
Moissl, Angela R.
Hennies, Mark
Tiedemann, Janina
Weltje, Lennart
Segner, Helmut
Braunbeck, Thomas
[J]. CHEMOSPHERE, 2020, 238
[7] Bixafen causes hepatotoxicity and pancreas toxicity in zebrafish (Danio rerio)
Wang, Yini
Peng, Huihan
Yu, Hailing
[J]. ECOTOXICOLOGY, 2023, 32 (07) : 837 - 844
[8] Danio rerio, the zebrafish
Wixon, J
[J]. YEAST, 2000, 17 (03) : 225 - 231
[9] Hepatotoxicity of benzotriazole and its effect on the cadmium induced toxicity in zebrafish Danio rerio
Duan, Zhenghua
Xing, Yanshuai
Feng, Zhitong
Zhang, Huiyuan
Li, Caixia
Gong, Zhiyuan
Wang, Lei
Sun, Hongwen
[J]. ENVIRONMENTAL POLLUTION, 2017, 224 : 706 - 713
[10] Effects of difenoconazole on hepatotoxicity, lipid metabolism and gut microbiota in zebrafish (Danio rerio)
Jiang, Jinhua
Chen, Liezhong
Wu, Shenggan
Lv, Lu
Liu, Xinju
Wang, Qiang
Zhao, Xueping
[J]. ENVIRONMENTAL POLLUTION, 2020, 265 (PT A)

← 1 2 3 4 5 →