Hydrolysis of an N-methylcarbamate by a catalytic antibody

被引：9
|
作者：
Dinaut, AN
Chen, MJ
Marks, A
Batey, RA
Taylor, SD
机构：
[1] Univ Toronto, Dept Chem, Mississauga, ON L5L 1C6, Canada
[2] Univ Toronto, Banting & Best Dept Med Res, Toronto, ON M5G 1L6, Canada
[3] Univ Toronto, Dept Chem, Toronto, ON M5S 1A1, Canada
来源：
CHEMICAL COMMUNICATIONS | 2000年 / 05期
关键词：
D O I：
10.1039/b000468p
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The first example of antibody-catalyzed hydrolysis of an N-methylcarbamate, a highly challenging reaction for antibody catalysis, was achieved by raising a monoclonal antibody to a phosphoramidate transition state analogue.
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页码：385 / 386
页数：2
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