Neuregulin 1 (NRG1) gene expression predicts functional outcomes in individuals at clinical high-risk for psychosis

被引：4
|
作者：
Jagannath, Vinita [1 ]
Gerstenberg, Miriam [1 ]
Walitza, Susanne [1 ,2 ,4 ,5 ,6 ]
Franscini, Maurizia [1 ]
Heekeren, Karsten [2 ,3 ]
Rossler, Wulf [2 ]
Theodoridou, Anastasia [2 ,3 ]
Grunblatt, Edna [1 ,4 ,5 ,6 ]
机构：
[1] Univ Zurich, Univ Hosp Psychiat Zurich, Dept Child & Adolescent Psychiat & Psychotherapy, Zurich, Switzerland
[2] Univ Hosp Psychiat Zurich, Zurich Program Sustainable Dev Mental Hlth Serv Z, Zurich, Switzerland
[3] Univ Zurich, Univ Hosp Psychiat Zurich, Dept Psychiat Psychotherapy & Psychosomat, Zurich, Switzerland
[4] Univ Zurich, Neurosci Ctr Zurich, Zurich, Switzerland
[5] Swiss Fed Inst Technol, Zurich, Switzerland
[6] Univ Zurich, Zurich Ctr Integrat Human Physiol, Zurich, Switzerland
来源：
PSYCHIATRY RESEARCH | 2018年 / 266卷
关键词：
At-risk psychosis; Ultra-high risk (UHR); High risk (HR); ULTRA-HIGH RISK; PERIPHERAL-BLOOD; SCHIZOPHRENIA; DISORDER; PEOPLE; SYMPTOMS; VARIANT;
D O I：
10.1016/j.psychres.2018.05.025
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
Little is known about valid predictive markers for functional outcomes in an at-risk for psychosis population. In a cohort of 185 individuals (age: 13-35 years) at high risk (I-IR) and ultra-high risk (UHR), we assessed pan-NRG1 mRNA levels across good functional status (GFS) and poor functional status (PFS) at baseline, and good functional outcome (GFO) and poor functional outcome (PFO) at 12-month follow-up. NRG1 mRNA levels were significantly higher in individuals with PFO than individuals with GFO at 12-month follow-up. Our findings suggest that NRG1 might emerge as a predictive marker for functional outcomes in at-risk for psychosis population.
引用
收藏
页码：143 / 146
页数：4
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