Incidence and predictors of postoperative ileus after loop ileostomy closure: a systematic review and meta-analysis

IntroductionPostoperative ileus (POI) is regarded as the most clinically significant morbidity following loop ileostomy closure; however, its incidence remains poorly understood. Our objective was therefore to determine the pooled incidence of POI after loop ileostomy closure and identify risk factors associated with its development.MethodsWe systematically searched MEDLINE (via Ovid and PubMed), Embase, the Cochrane Library, Biosis Previews, and Scopus to identify studies reporting the incidence of POI in patients who underwent loop ileostomy closure. Two independent reviewers extracted data and appraised study quality. Cumulative incidence proportions were pooled across studies using a random-effects meta-analytic model.ResultsSixty-seven studies, including 9528 patients, met our inclusion criteria. The pooled estimate of POI was 8.0% (95% CI 6.9-9.3%; I-2=74%). The estimated incidence varied by POI definition: studies with a robust definition of POI (n=8) demonstrated the highest estimate of POI (12.4%, 95% CI 9.2-16.5%; I-2=79%) while studies that did not report an explicit POI definition (n=38) demonstrated the lowest estimate (6.7%, 95% CI 5.3-8.3%; I-2=61%). Small bowel anastomosis technique (hand-sewn) and interval time from ileostomy creation to closure (longer time) were the factors most commonly associated with POI after loop ileostomy closure. However, most comparative studies were not powered to examine risk factors for POI.ConclusionsPOI is an important complication after loop ileostomy closure, and its incidence is dependent on its definition. More research aimed at studying this complication is required to better understand risk factors for POI after loop ileostomy closure.