Comparison of Clinical Characteristics of Human Metapneumovirus and Respiratory Syncytial Virus Infections in Hospitalized Young Children

被引：15

作者：

Taniguchi, Akinobu ^{[1
,3
]}

Kawada, Jun-ichi ^{[1
]}

Go, Kiyotaka ^{[1
]}

Fujishiro, Naozumi ^{[1
]}

Hosokawa, Yosuke ^{[1
]}

Maki, Yuki ^{[1
]}

Sugiyama, Yuichiro ^{[1
]}

Suzuki, Michio ^{[4
]}

Tsuji, Takeshi ^{[5
]}

Hoshino, Shin ^{[6
]}

Muramatsu, Hideki ^{[1
]}

Kidokoro, Hiroyuki ^{[1
]}

Kinoshita, Fumie ^{[7
]}

Hirakawa, Akihiro ^{[7
,9
]}

Takahashi, Yoshiyuki ^{[1
]}

Sato, Yoshiaki ^{[1
,8
]}

Natsume, Jun ^{[1
,2
]}

Yamakawa, Kiyoshi ^{[10
]}

Okumura, Akihisa ^{[10
]}

Kato, Toru ^{[11
]}

Nagai, Noriko ^{[11
]}

Moriyama, Miyako ^{[12
]}

Miyajima, Yuji ^{[12
]}

Yamamori, Kazuki ^{[13
]}

Shibata, Motohiro ^{[13
]}

Hasegawa, Masayuki ^{[14
]}

Shinohara, Osamu ^{[15
]}

Nishimura, Naoko ^{[16
]}

Aoshima, Tsutomu ^{[17
]}

Morishita, Masashi ^{[18
]}

Nomura, Yoji ^{[19
]}

Kuraishi, Kenji ^{[19
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Pediat, Nagoya, Aichi 4668550, Japan

[2] Nagoya Univ, Dept Dev Disabil Med, Grad Sch Med, Nagoya, Aichi 4668550, Japan

[3] Ogaki Municipal Hosp, Dept Neonatol, Ogaki 5038502, Japan

[4] Nagoya Mem Hosp, Dept Pediat, Nagoya, Aichi 4680011, Japan

[5] Okazaki City Hosp, Dept Pediat, Okazaki, Aichi 4448553, Japan

[6] Kasugai City Hosp, Dept Pediat, Kasugai, Aichi 4868510, Japan

[7] Nagoya Univ Hosp, Ctr Adv Med & Clin Res, Nagoya, Aichi 4668550, Japan

[8] Nagoya Univ Hosp, Div Neonatol, Ctr Maternal Neonatal Care, Nagoya, Aichi 4668550, Japan

[9] Univ Tokyo, Dept Biostat & Bioinformat, Grad Sch Med, Tokyo 1138655, Japan

[10] Aichi Med Univ Hosp, Nagakute, Aichi, Japan

[11] Okazaki City Hosp, Okazaki, Aichi, Japan

[12] Anjo Kosei Hosp, Anjo, Aichi, Japan

[13] Chukyo Hosp, Nagoya, Aichi, Japan

[14] Nagoya Ekisaikai Hosp, Nagoya, Aichi, Japan

[15] Handa City Hosp, Handa, Aichi, Japan

[16] Konan Kosei Hosp, Konan, Aichi, Japan

[17] Nishichita Gen Hosp, Tokai, Aichi, Japan

[18] Tosei Gen Hosp, Seto, Aichi, Japan

[19] Ogaki Municipal Hosp, Ogaki, Gifu, Japan

来源：

JAPANESE JOURNAL OF INFECTIOUS DISEASES | 2019年 / 72卷 / 04期

基金：

日本学术振兴会;

关键词：

TRACT INFECTIONS; DISEASE; PCR;

D O I：

10.7883/yoken.JJID.2018.480

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Human metapneumovirus (HMPV) and respiratory syncytial virus (RSV) are the leading causes of acute respiratory tract infection in children, and clinical manifestations of these virus infections are considered similar. To investigate the differences in clinical characteristics between HMPV and RSV infections in young children, we prospectively enrolled children < 3 years old who required hospitalization with acute respiratory tract infection due to HMPV or RSV at 10 hospitals in Japan. We enrolled 48 children with HMPV infection and 141 with RSV infection. Patients with HMPV infection were older than those with RSV infection. High-grade fever was more frequently observed in patients with HMPV infection, whereas no significant differences in respiratory symptoms were apparent. Abnormal serum lactate dehydrogenase values and consolidation shadows on chest X-ray were more frequently observed in patients with HMPV infection. During hospitalization, nasal mucus suction was more frequently required in patients with RSV infection. On the other hand, beta 2-adrenergic agonists, corticosteroids, and leukotriene receptor antagonists were more frequently used in patients with HMPV infection. These findings suggest that HMPV and RSV infections show similar respiratory symptoms, but HMPV infection is more likely to lead to the development of pneumonia, at least among hospitalized young children.

引用

页码：237 / 242

页数：6

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