Full-field interferometric confocal microscopy using a VCSEL array

被引:32
|
作者
Redding, Brandon [1 ]
Bromberg, Yaron [1 ]
Choma, Michael A. [2 ,3 ]
Cao, Hui [1 ]
机构
[1] Yale Univ, Dept Appl Phys, New Haven, CT 06520 USA
[2] Yale Sch Med, Dept Diagnost Radiol, New Haven, CT 06520 USA
[3] Yale Univ, Dept Biomed Engn, New Haven, CT 06520 USA
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
OPTICAL COHERENCE TOMOGRAPHY; SPATIALLY INCOHERENT ILLUMINATION; LINE-SCANNING MICROSCOPE; IMAGING HUMAN TISSUES; SPECKLE ILLUMINATION; PHASE MICROSCOPY; IN-VIVO; RESOLUTION; SYSTEMS; PERFORMANCE;
D O I
10.1364/OL.39.004446
中图分类号
O43 [光学];
学科分类号
070207 ; 0803 ;
摘要
We present an interferometric confocal microscope using an array of 1200 vertical cavity surface emitting lasers (VCSELs) coupled to a multimode fiber. Spatial coherence gating provides similar to 18,000 continuous virtual pinholes, allowing an entire en face plane to be imaged in a snapshot. This approach maintains the same optical sectioning as a scanning confocal microscope without moving parts, while the high power of the VCSEL array (similar to 5 mW per laser) enables high-speed image acquisition with integration times as short as 100 mu s. Interferometric detection also recovers the phase of the image, enabling quantitative phase measurements and improving the contrast when imaging phase objects. (C) 2014 Optical Society of America
引用
收藏
页码:4446 / 4449
页数:4
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