Levothyroxine dosage and the limitations of current bioequivalence standards

被引：20
|
作者：
Hennessey, James V. [1 ]
机构：
[1] Brown Univ, Rhode Isl Hosp, Hallett Ctr Diabet & Endocrinol, Providence, RI 02903 USA
来源：
NATURE CLINICAL PRACTICE ENDOCRINOLOGY & METABOLISM | 2006年 / 2卷 / 09期
关键词：
D O I：
10.1038/ncpendmet0273
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
FDA regulation of levothyroxine formulations aims to ensure consistent drug content and bioavailability of brand name and generic products. This Viewpoint suggests that the pharmacokinetic measure of therapeutic equivalence in current use—measurement of total T4levels in the blood—might not be sufficiently reliable to achieve these goals.
引用
收藏
页码：474 / 475
页数：2
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