The IL-6/JAK/STAT3 pathway: Potential therapeutic strategies in treating colorectal cancer (Review)

被引：269

作者：

Wang, Shu-Wei ^{[1
]}

Sun, Yue-Ming ^{[1
]}

机构：

[1] Nanjing Med Univ, Dept Minimally Invas Surg, Affiliated Hosp 1, Nanjing 210029, Jiangsu, Peoples R China

来源：

INTERNATIONAL JOURNAL OF ONCOLOGY | 2014年 / 44卷 / 04期

关键词：

interleukin-6; Janus kinase; signal transducer and activator of transcription 3; therapies; colorectal cancer; INFLAMMATORY-BOWEL-DISEASE; STAT3 SIGNALING PATHWAY; CELL-CYCLE ARREST; INTESTINAL EPITHELIAL-CELLS; SERUM INTERLEUKIN-6 LEVELS; IN-VIVO; COLON-CANCER; HEPATOCELLULAR-CARCINOMA; ULCERATIVE-COLITIS; MOUSE MODEL;

D O I：

10.3892/ijo.2014.2259

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Among the cytokines linked to inflammation-associated cancer, interleukin (IL)-6 drives many of the cancer hallmarks' through downstream activation of the Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) signaling pathway. Additionally, dysregulation of the interleukin (IL)-6-mediated JAK/STAT3 signaling pathway is closely related to the development of diverse human solid tumors including colorectal cancer (CRC). On this basis, modulation of the IL-6/JAK/STAT3 signaling pathway is currently being widely explored to develop novel therapies for CRC. The present review details the mechanisms and roles of the IL-6/JAK/STAT3 pathway in CRC, describes current therapeutic strategies, and the search for potential therapeutic approaches to treat CRC.

引用

页码：1032 / 1040

页数：9

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