Frontal Variant of Alzheimer Disease Differentiated From Frontotemporal Dementia Using in Vivo Amyloid and Tau Imaging

被引:7
|
作者
Paquin, Vincent [1 ,2 ]
Therriault, Joseph [3 ,4 ,5 ]
Pascoal, Tharick Ali [3 ,4 ,5 ]
Rosa-Neto, Pedro [2 ,3 ,4 ,5 ]
Gauthier, Serge [2 ,3 ,4 ]
机构
[1] Douglas Res Ctr, Mental Hlth & Soc Div, Montreal, PQ, Canada
[2] McGill Univ, Dept Psychiat, Montreal, PQ, Canada
[3] McGill Univ, Dept Neurol & Neurosurg, Montreal, PQ, Canada
[4] McGill Univ, McGill Univ Res Ctr Studies Aging, Douglas Res Ctr, Translat Neuroimaging Lab, Montreal, PQ, Canada
[5] Montreal Neurol Inst, Montreal, PQ, Canada
基金
加拿大健康研究院;
关键词
Alzheimer disease; positron-emission tomography; frontal; executive function; behavior; MONTREAL COGNITIVE ASSESSMENT; BEHAVIORAL VARIANT; DIAGNOSIS;
D O I
10.1097/WNN.0000000000000251
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
The frontal variant of Alzheimer disease (fvAD) is characterized by behavioral and/or dysexecutive impairments that can resemble those of behavioral-variant frontotemporal dementia (bvFTD). This overlap, in addition to the lack of consensus clinical criteria for fvAD, complicates its identification. We provide the first case report of fvAD differentiated in vivo from bvFTD using amyloid-beta and tau PET imaging. The patient, a right-handed woman, presented with forgetfulness at age 60. Cognitive testing at that time revealed mild impairments in memory, attention, and executive functions. Three years later, her family reported that she was displaying socially inappropriate behaviors, inertia, diminished social interest, and altered food preferences-the sum of which met the criteria for possible bvFTD. PET using an amyloid-beta tracer (F-18-AZD4694) identified diffuse amyloid plaques across the cerebral cortex. PET using a tau tracer specific for neurofibrillary tangles (F-18-MK6240) identified substantial tau pathology in the brain's frontal lobes. Together with the clinical findings, these images supported the diagnosis of fvAD rather than bvFTD. Considering past and emerging evidence that tau topography in Alzheimer disease (AD) matches the clinical features of AD, we discuss the potential utility of in vivo tau imaging using F-18-MK6240 for identifying fvAD.
引用
收藏
页码:288 / 293
页数:6
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