State-of-the-art dried blood spot analysis: an overview of recent advances and future trends

被引：0

作者：

Meesters, Roland J. W. ^{[1
]}

Hooff, Gero P. ^{[2
]}

机构：

[1] Univ Los Andes, Fac Sci, Dept Chem, Bogota, Colombia

[2] MSD Anim Hlth Innovat GmbH, D-55270 Zur Propstei, Schwabenheim, Germany

来源：

BIOANALYSIS | 2013年 / 5卷 / 17期

关键词：

PERFORMANCE LIQUID-CHROMATOGRAPHY; TANDEM MASS-SPECTROMETRY; REAL-TIME PCR; GAMMA-HYDROXYBUTYRIC ACID; MINIMALLY INVASIVE METHOD; SOLID-PHASE EXTRACTION; WHOLE-BLOOD; FILTER-PAPER; AMINO-ACIDS; SAMPLE PREPARATION;

D O I：

10.4155/BIO.13.175

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Dried blood spots have become a popular method in a variety of micro blood-sampling techniques in the life sciences sector, consequently competing with the field of conventional, invasive blood sampling by venepuncture. Dried blood spots are widely applied in numerous bioanalytical assays and have gained a significant role in the screening of inherited metabolic diseases, in PK and PD modeling; in the treatment and diagnosis of infectious diseases; and in therapeutic drug monitoring. Recent technological developments such as automation, online extraction, mass spectrometric direct analysis and also conventional dried blood spot bioanalysis, as well as future developments in dried blood spot bioanalysis are highlighted and presented in this article.

引用

页码：2187 / 2208

页数：22

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