Cannabis extract for the treatment of painful tonic spasms in a patient with neuromyelitis optica spectrum disorder: A case report

被引：0
|
作者：
Tisavipat, Nanthaya [1 ]
Siritho, Sasitorn [2 ,3 ,4 ]
Prayoonwiwat, Naraporn [2 ,3 ]
Jitprapaikulsan, Jiraporn [2 ,3 ]
机构：
[1] Mahidol Univ, Fac Med, Siriraj Hosp, Bangkok 10700, Thailand
[2] Mahidol Univ, Div Neurol, Dept Med, Fac Med,Siriraj Hosp, Bangkok 10700, Thailand
[3] Mahidol Univ, Siriraj Neuroimmunol Ctr, Fac Med, Siriraj Hosp, Bangkok 10700, Thailand
[4] Bumrungrad Int Hosp, Bangkok 10110, Thailand
来源：
MULTIPLE SCLEROSIS AND RELATED DISORDERS | 2020年 / 44卷
关键词：
Neuromyelitis optica (NMO); Painful tonic spasm; Longitudinally extensive transverse myelitis; Cannabis; THC; Carbamazepine; SPASTICITY;
D O I：
10.1016/j.msard.2020.102278
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Painful tonic spasm (PTS) is a common yet debilitating symptom in patients with neuromyelitis optica spectrum disorder (NMOSD), especially those with longitudinally extensive transverse myelitis. Although carbamazepine is an effective treatment, it poses the risk of severe adverse reactions, such as Steven-Johnson syndrome (SJS). In this case report, we describe an NMOSD patient with severe PTS suffering from carbamazepine-induced SJS who responded well to cannabis extract. Since cannabinoids can ameliorate spasticity in an experimental autoimmune encephalomyelitis model through cannabinoid 1 (CB1) receptor activation, cannabis extract which includes delta-9-tetrahydrocannabinol (THC) is a potential treatment option for PTS in NMOSD patients.
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页数：3
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