Significant increase of CKS1B amplification from monoclonal gammopathy of undetermined significance to multiple myeloma and plasma cell leukaemia as demonstrated by interphase fluorescence in situ hybridisation

被引：30
|
作者：
Chang, Hong
Yeung, Joanna
Xu, Wei
Ning, Yi
Patterson, Bruce
机构：
[1] Univ Toronto, Univ Hlth Network, Dept Lab Hematol, Toronto, ON, Canada
[2] Univ Toronto, Univ Hlth Network, Dept Lab Med & Pathobiol, Toronto, ON, Canada
[3] Univ Maryland, Dept Cytogenet, Baltimore, MD 21201 USA
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2006年 / 134卷 / 06期
关键词：
plasma cell dyscrasia; CKS1B; fluorescence in situ hybridisation; tumour progression; monoclonal gammopathy of undetermined significance;
D O I：
10.1111/j.1365-2141.2006.06237.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The genetic events that lead to tumour progression in plasma cell dyscrasia are not well understood. Interphase cytoplasmic fluorescence in situ hybridisation was used to investigate the CKS1B amplification status (at 1q21) in clonal plasma cells from 123 patients: 23 monoclonal gammopathy of undetermined significance (MGUS), 75 multiple myeloma (MM) and 26 plasma cell leukaemia (PCL). While CKS1B amplification was absent in MGUS patients, such amplification (3-8 copies) was detected in 36% of newly diagnosed MM, 52% relapsed MM and 62% PCL (P < 0.001). Our results suggest that CKS1B amplification is associated with transformation from MGUS to MM and progression to PCL.
引用
收藏
页码：613 / 615
页数：3
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