Role of Endogenous Melatonin in the Regulation of Th17/Treg Balance during Pregnancy

被引：11
|
作者：
Glebezdina, N. S. [1 ]
Olina, A. A. [2 ]
Nekrasova, I. V. [1 ]
Kuklina, E. M. [1 ]
机构：
[1] Russian Acad Sci, Inst Ecol & Genet Microorganisms, Ural Branch, Perm, Russia
[2] EA Wagner Perm State Med Univ, Perm, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2018年 / 164卷 / 04期
基金：
俄罗斯基础研究基金会;
关键词：
differentiation; Th17; Treg; melatonin; pregnancy; T-CELL PARADIGM; ROR-ALPHA; DIFFERENTIATION; RECEPTORS; PREECLAMPSIA; EXPRESSION; GAMMA; FOXP3; TH17;
D O I：
10.1007/s10517-018-4013-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
We studied the role of endogenous melatonin in the development and functioning of T cells that produce IL-17 (Th17) and regulatory T cells (Treg) during pregnancy. The study was performed ex vivo and in vitro with auto-serum as the source of endogenous melatonin under conditions of blockade of melatonin-dependent signaling. Participation of the hormone in the regulation of differentiation of both CD4(+)ROR gamma t(+) and CD4(+)FoxP3(+)T cells and their key products IL-17A and TGF-beta was demonstrated. It is known that the normal gestational process is accompanied by a decrease in Th17/Treg ratio due to hormonal changes. The sensitivity of the studied subpopulations to melatonin during pregnancy can affect its outcome.
引用
收藏
页码：462 / 465
页数：4
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