Human 17β-hydroxysteroid dehydrogenase type 5 is inhibited by dietary flavonoids

被引:0
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作者
Krazeisen, A [1 ]
Breitling, R [1 ]
Möller, G [1 ]
Adamski, J [1 ]
机构
[1] GSF Natl Res Ctr Environm & Hlth, Inst Expt Genet, Genome Anal Ctr, D-85764 Neuherberg, Germany
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中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Phytoestrogens contained in a vegetarian diet are supposed to have beneficial effects on the development and progression of a variety of endocrine-related cancers. We have tested the effect of a variety of dietary phytoestrogens, especially flavonoids, on the activity of human 17beta-hydroxysteroid dehydrogenase type 5 (17beta-HSD 5), a key enzyme in the metabolism of estrogens and androgens. Our studies show that reductive and oxidative activity of the enzyme are inhibited by many compounds, especially zearalenone, coumestrol, quercetin and biochanin A. Among flavones, inhibitor potency is enhanced with increased degree of hydroxylation. The most effective inhibitors seem to bind to the hydrophilic cofactor binding pocket of the enzyme.
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页码:151 / 161
页数:11
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