Cellular localization of bradykinin B-1 receptor mRNA in the human kidney

被引：6
|
作者：
Wang, DZ [1 ]
Chao, L [1 ]
Chao, J [1 ]
机构：
[1] MED UNIV S CAROLINA,DEPT BIOCHEM & MOL BIOL,CHARLESTON,SC 29425
来源：
IMMUNOPHARMACOLOGY | 1996年 / 33卷 / 1-3期
关键词：
bradykinin B-1 receptor; mRNA; kidney; renal cell carcinoma;
D O I：
10.1016/0162-3109(96)00011-2
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Cellular localization of the B-1 receptor mRNA in the human kidney was identified by in situ hybridization histochemistry using digoxigenin-labeled riboprobe. With the antisense riboprobe, the B-1 receptor mRNA was found mostly in the parietal layer of Bowman's capsule and the thin segment of Henle's loop. The renal carcinoma cells were stained with the B-1 receptor riboprobe. These results showed the cellular localization of human renal B-1 receptor mRNA and revealed sites of bradykinin action in regulating renal function under normal and pathological conditions.
引用
收藏
页码：151 / 156
页数：6
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