A Pathophysiological Perspective on the SARS-CoV-2 Coagulopathy

被引：5

作者：

Kusadasi, Nuray ^{[1
]}

Sikma, Maaike ^{[1
,2
]}

Huisman, Albert ^{[3
]}

Westerink, Jan ^{[4
]}

Maas, Coen ^{[3
]}

Schutgens, Roger ^{[5
]}

机构：

[1] Univ Med Ctr Utrecht, Dept Intens Care Med, Utrecht, Netherlands

[2] Univ Med Ctr Utrecht, Dutch Poisons Informat Ctr, Utrecht, Netherlands

[3] Univ Med Ctr Utrecht, Cent Diagnost Lab, Utrecht, Netherlands

[4] Univ Med Ctr Utrecht, Dept Vasc Med, Utrecht, Netherlands

[5] Univ Med Ctr Utrecht, Benign Hematol Ctr, Van Creveldklin, Utrecht, Netherlands

来源：

HEMASPHERE | 2020年 / 4卷 / 04期

关键词：

THROMBIN; INHIBITOR; ADHESION; PATHWAY; TISSUE; CELLS;

D O I：

10.1097/HS9.0000000000000457

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent evidence is focusing on the presence of a hypercoagulable state with development of both venous and arterial thromboembolic complications in patients infected with SARS-CoV-2. The ongoing activation of coagulation related to the severity of the illness is further characterized by thrombotic microangiopathy and endotheliitis. These microangiopathic changes cannot be classified as classical disseminated intravascular coagulation (DIC). In this short review we describe the interaction between coagulation and inflammation with focus on the possible mechanisms that might be involved in SARS-CoV-2 infection associated coagulopathy in the critically ill.

引用

页数：6

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