Highly efficient Pd-catalyzed synthesis of nitriles from aldoximes

被引：76
|
作者：
Kim, Hoo Sook
Kim, Sung Hwan
Kim, Jae Nyoung [1 ]
机构：
[1] Chonnam Natl Univ, Dept Chem, Kwangju 500757, South Korea
来源：
TETRAHEDRON LETTERS | 2009年 / 50卷 / 15期
关键词：
Palladium; Nitriles; Aldoximes; ALLYLATED OXIME ETHERS; HECK-TYPE CYCLIZATION; C-H BONDS; HETEROGENEOUS CATALYST; ALLYLIC SUBSTITUTION; AROMATIC NITRILES; PRIMARY AMIDES; ARYL HALIDES; DEHYDRATION; OXYGENATION;
D O I：
10.1016/j.tetlet.2009.01.150
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An expedient method of Pd-catalyzed conversion of aldoxime into nitrile was developed. The reaction was carried out under the influence of Pd(OAc)(2)/PPh3 in refluxing CH3CN to provide good to high yields. The use of Cs2CO3 (0.1-0.5 equiv) was crucial in some cases. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1717 / 1719
页数：3
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