Farnesyltransferase inhibitor suppresses nitric oxide production and iNOS expression by blocking p21ras-dependent NF-κB activation

被引:0
|
作者
Kim, YM [1 ]
Na, HJ [1 ]
Lee, SJ [1 ]
Nam, WD [1 ]
Han, JA [1 ]
Ha, KS [1 ]
Kwon, YG [1 ]
机构
[1] Kangweon Natl Univ, Sch Med, Dept Orthopaed Surg, Kangwon Do, South Korea
来源
NITRIC OXIDE-BIOLOGY AND CHEMISTRY | 2004年 / 11卷 / 01期
关键词
D O I
暂无
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:98 / 98
页数:1
相关论文
共 50 条
  • [1] Inhibition of farnesyltransferase prevents collagen-induced arthritis by down-regulation of inflammatory gene expression through suppression of p21ras-dependent NF-κB activation
    Na, HJ
    Lee, SJ
    Kang, YC
    Cho, YL
    Nam, WD
    Kim, PKM
    Ha, KS
    Chung, HT
    Lee, H
    Kwon, YG
    Koh, JS
    Kim, YM
    JOURNAL OF IMMUNOLOGY, 2004, 173 (02): : 1276 - 1283
  • [2] Inhibitory effect of inflexinol on nitric oxide generation and iNOS expression via inhibition of NF-κB activation
    Lee, Jae Woong
    Lee, Moon Soon
    Kim, Tae Hun
    Lee, Hwa Jeong
    Hong, Seong Su
    Noh, Young Hee
    Hwang, Bang Yeon
    Ro, Jai Seup
    Hong, Jin Tae
    MEDIATORS OF INFLAMMATION, 2007, 2007
  • [3] Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing IκB kinase-dependent NF-κB activation
    Lee, SJ
    Bai, SK
    Lee, KS
    Namkoong, S
    Na, HJ
    Ha, KS
    Han, JA
    Yim, SV
    Chang, K
    Kwon, YG
    Lee, SK
    Kim, YM
    MOLECULES AND CELLS, 2003, 16 (01) : 97 - 105
  • [4] Beryllium fluoride-induced cell proliferation:: a process requiring P21ras-dependent activated signal transduction and NF-κB-dependent gene regulation
    Misra, UK
    Gawdi, G
    Pizzo, SV
    JOURNAL OF LEUKOCYTE BIOLOGY, 2002, 71 (03) : 487 - 494
  • [5] INHIBITION OF LIPOPOLYSACCHARIDE-INDUCIBLE NITRIC OXIDE SYNTHASE EXPRESSION BY CROTON DITERPENOIDS THROUGH BLOCKING OF NF-κB ACTIVATION
    Kim, Sang Eun
    Oh, Won Keun
    Kang, Keon Wook
    DRUG METABOLISM REVIEWS, 2008, 40 : 82 - 82
  • [6] Acetylaminofluorene inhibits nitric oxide production in LPS-stimulated RAW 264.7 cells by blocking NF-κB/Rel activation
    Jeon, YJ
    Han, SH
    Kang, JS
    Koh, WS
    Yang, KH
    TOXICOLOGY LETTERS, 1999, 104 (03) : 195 - 202
  • [7] Inhibition of iNOS expression and no production by flavonoids.: Effects on the activation of STAT-1 and NF-κB
    Hamalainen, M.
    Nieminen, R.
    Vuorela, P.
    Heinonen, M.
    Moilanen, E.
    BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY, 2008, 102 : 42 - 42
  • [8] Insulin suppresses LPS-induced iNOS and COX-2 expression and NF-κB activation in alveolar macrophages
    Martins, Joilson O.
    Ferracini, Matheus
    Ravanelli, Natalia
    Landgraf, Richardt G.
    Jancar, Sonia
    CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2008, 22 (1-4) : 279 - 286
  • [9] Cannabidiol inhibits inducible nitric oxide synthase (iNOS) expression via inhibition of P38 MAPK and NF-κB in microglial cells
    Haasan, S.
    El-Deeb, K.
    Chatterton, D.
    Latif, L.
    Alexander, S.
    Kendall, D.
    BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2012, 73 (06) : 993 - 993
  • [10] Inhibitory effect of citral on NO production by suppression of iNOS expression and NF-κB activation in RAW264.7 cells
    Lee, Hwa Jeong
    Jeong, Heon Sang
    Kim, Dae Joong
    Noh, Young Hee
    Yuk, Dong Yeon
    Hong, Jin Tae
    ARCHIVES OF PHARMACAL RESEARCH, 2008, 31 (03) : 342 - 349