Patterns of decline in naming and semantic knowledge in primary progressive aphasia

被引:27
|
作者
Sebastian, Rajani [1 ]
Thompson, Carol B. [2 ]
Wang, Nae-Yuh [2 ,3 ,4 ,5 ]
Wright, Amy [1 ]
Meyer, Aaron [6 ]
Friedman, Rhonda B. [6 ]
Hillis, Argye E. [1 ,7 ,8 ]
Tippett, Donna C. [1 ,7 ,9 ]
机构
[1] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
[2] Johns Hopkins Bloomberg Sch Publ Hlth, Johns Hopkins Biostat Ctr, Baltimore, MD USA
[3] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA
[4] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA
[5] Johns Hopkins Bloomberg Sch Publ Hlth, Welch Ctr Prevent Epidemiol & Clin Res, Baltimore, MD USA
[6] Georgetown Univ, Med Ctr, Cognit Neuropsychol Lab, Ctr Aphasia Res & Rehabil, Washington, DC 20007 USA
[7] Johns Hopkins Univ, Sch Med, Dept Phys Med & Rehabil, Baltimore, MD USA
[8] Johns Hopkins Univ, Dept Cognit Sci, Baltimore, MD 21218 USA
[9] Johns Hopkins Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 601 N Caroline St,6th Floor, Baltimore, MD 21287 USA
关键词
Primary progressive aphasia; nonfluent agrammatic primary progressive aphasia; semantic variant primary progressive aphasia; logopenic variant primary progressive aphasia; language symptoms; FRONTOTEMPORAL LOBAR DEGENERATION; ALZHEIMERS-DISEASE; LOGOPENIC VARIANT; WORD COMPREHENSION; NATURAL-HISTORY; DEMENTIA; PATHOLOGY; DETERIORATION; CLASSIFICATION; ATROPHY;
D O I
10.1080/02687038.2018.1490388
中图分类号
R36 [病理学]; R76 [耳鼻咽喉科学];
学科分类号
100104 ; 100213 ;
摘要
Background: Individuals with primary progressive aphasia (PPA) and their caregivers want to know what to expect so that they can plan support appropriately. The ability to predict decline in naming and semantic knowledge, and advise individuals with PPA and their caregivers regarding future planning, would be invaluable clinically.Aims: The aims of this study were to investigate patterns of decline in naming and semantic knowledge in each of the clinical variants of PPA (logopenic variant PPA, lvPPA; nonfluent agrammatic PPA, nfaPPA; and semantic variant PPA, svPPA) and to examine the effects of other variables on rate of decline. We hypothesized that speech-language rehabilitation, higher education, and higher baseline test scores would be associated with slower decline, and older age with faster decline.Methods and Procedures: A total of 94 participants with PPA underwent language testing, including 36 participants with lvPPA, 31 participants with nfaPPA, and 27 participants with svPPA. All participant groups were similar in age and education. We focused on decline on three tests: the short form of the Boston Naming Test (BNT), the Hopkins Assessment of Naming Actions (HANA), and the short form of the Pyramids and Palm Trees Test (PPTT).Outcome and Results: Across language tests, the most precipitous rates of decline (loss of points per month) occurred in nfaPPA, followed by svPPA, then lvPPA. Female sex, longer symptom duration, higher baseline test score, and speech-language rehabilitation were associated with slower decline.Conclusions: PPA variants were distinguishable by rapidity of decline, with nfaPPA having the most precipitous decline. As hypothesized, higher baseline test scores and speech-language rehabilitation were associated with slower decline. Surprisingly, age and education were not important prognostically for individuals in this study. Further study of prognostically-relevant variables in PPA is indicated in this population.
引用
收藏
页码:1010 / 1030
页数:21
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